The benign lesions include cystitis cystica, cystitis glandularis, von Brunn nests, nephrogenic adenoma, mesonephric remnant, intestinal metaplasia, and urachal remnant.
However, florid von Brunn nests, the nested variant of urothelial carcinoma, and urothelial carcinoma involving von Brunn nests can mimic adenocarcinoma.
Urothelial carcinoma can extend into von Brunn nests, mimicking adenocarcinoma.
Large nested variant of urothelial carcinoma: 23 cases mimicking von brunn nests
and inverted growth pattern of noninvasive papillary urothelial carcinoma.
von Brunn nests are present in the normal urothelium and are thought to arise from invaginations of the urothelial mucosa into the underlying lamina propria.
Cystitis cystica is a benign urothelial lesion characterized by the presence of cystically dilated von Brunn nests.
Von Brunn nests in lamina propria, including cystitis cystica (Figure 2, E and F; arrow), were similarly straight forward to identify.
In addition to carcinomas, a variety of benign lesions were readily identifiable by MPM, which might appear cystoscopically suspicious for carcinoma, including cystitis cystica and florid proliferations of von Brunn nests.
The ability of MPM to provide real-time diagnoses of benign entities, such as cystitis cystica and proliferation of von Brunn nests, could direct urologists in further evaluation and sampling of the patient with urine cytology suspicious or diagnostic of carcinoma.
Von Brunn nests are aggregates of urothelial cells that represent invaginations from the surface urothelium.
These represent a continuum of proliferative and presumed reactive changes that can involve von Brunn nests anywhere along the urinary tract and are usually named accordingly (cystitis cystica, ureteritis cystica, urethritis cystica).
The biopsy specimen showed BPEPs (PSA-positive glands) and foci of von Brunn nests