Brufen


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ibuprofen

Actiprofen Caplets (CA), Advil, Advil Extra Strength (CA), Advil Migraine, Advil Pediatric Drops, Anadin Ibuprofen (UK), Anadin Ultra (UK), Apo-Ibuprofen (CA), Arthrofen (UK), Brufen (UK), Caldolor, Calprofen (UK), Children's Advil, Children's Motrin, Cuprofen (UK), Extra Strength Motrin IB (CA), Hedex Ibuprofen (UK), Ibugel (UK), Ibuleve (UK), Ibumousse (UK), Ibuspray (UK), Junior Strength Advil, Junior Strength Motrin, Motrin, Motrin IB, Motrin Infant, NeoProfen, Novo-Profen, Nu-Ibuprofen (CA), Nurofen (UK), PMS-Ibuprofen (CA)

Pharmacologic class: Nonsteroidal anti-inflammatory drug (NSAID)

Therapeutic class: Analgesic, antipyretic, anti-inflammatory

Pregnancy risk category B (third trimester: D)

Pregnancy risk category B (third trimester: D)

FDA Box Warning

• Drug may increase risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke. Risk may increase with duration of use, and may be greater in patients who have cardiovascular disease or risk factors for it.

• Drug is contraindicated for perioperative pain in setting of coronary artery bypass graft surgery.

• Drug increases risk of serious GI adverse events, including bleeding, ulcers, and stomach or intestinal perforation, which can be fatal. These events can occur at any time during therapy and without warning. Elderly patients are at greater risk.

Action

Unknown. Thought to inhibit cyclooxygenase, an enzyme needed for prostaglandin synthesis.

Availability

Capsules (liquigels): 200 mg

Injection: 400 mg/4-ml, 800 mg/8-ml vials

Oral suspension: 100 mg/5 ml

Pediatric drops: 50 mg/1.25 ml

Tablets: 100 mg, 200 mg, 400 mg, 600 mg, 800 mg

Tablets (chewable): 50 mg, 100 mg

Indications and dosages

Rheumatoid arthritis; osteoarthritis

Adults: 1.2 to 3.2 g/day P.O. in three to four divided doses

Mild to moderate pain

Adults: 400 mg P.O. q 4 to 6 hours p.r.n. or 400 to 800 mg I.V. over 30 minutes q 6 hours, as necessary

Moderate to severe pain as adjunct to opioid analgesics

Adults: 400 to 800 mg I.V. over 30 minutes q 6 hours, as necessary

Fever reduction

Adults: 400 mg I.V. over 30 minutes, followed by 400 mg P.O. q 4 to 6 hours or 100 to 200 mg P.O. q 4 hours as necessary

Primary dysmenorrhea

Adults: 400 mg P.O. q 4 hours p.r.n.

Juvenile arthritis

Children: 30 to 40 mg/kg/day P.O. in three or four divided doses. Daily dosages above 50 mg/kg aren't recommended.

Fever reduction; pain relief

Children ages 6 to 12: 5 mg/kg P.O. if temperature is below 102.5 °F (39.2 °C) or 10 mg/kg if temperature is above 102.5 °F. Maximum daily dosage is 40 mg/kg.

Off-label uses

• Migraine and tension headaches

Contraindications

• Hypersensitivity to drug or other NSAIDs
• Perioperative use in coronary artery bypass graft surgery

Precautions

Use cautiously in:
• severe cardiovascular, renal, or hepatic disease; GI disease; asthma; chronic alcohol use
• elderly patients
• pregnant (avoid use after 30 weeks' gestation) or breastfeeding patients
• children younger than age 17 (safety and efficacy not established).

Administration

• Ideally, give oral form 1 hour before or 2 hours after meal. If GI upset occurs, give with meals.
• Be aware that patients must be well hydrated before I.V. form is administered.
• Dilute injection form before administering.

Adverse reactions

CNS: headache, dizziness, drowsiness, nervousness, aseptic meningitis

CV: hypertension, arrhythmias

EENT: amblyopia, blurred vision, tinnitus

GI: nausea, vomiting, constipation, dyspepsia, abdominal discomfort, GI bleeding

GU: cystitis, hematuria, azotemia, renal failure

Hematologic: anemia, prolonged bleeding time, aplastic anemia, neutropenia, pancytopenia, thrombocytopenia, leukopenia, agranulocytosis

Hepatic: hepatitis

Metabolic: hyperglycemia, hypoglycemia

Respiratory: bronchospasm

Skin: rash, pruritus, urticaria, Stevens-Johnson syndrome

Other: edema, allergic reactions including anaphylaxis

Interactions

Drug-drug.Antihypertensives, diuretics: decreased efficacy of these drugs

Aspirin and other NSAIDs, corticosteroids: additive adverse GI effects

Cefamandole, cefoperazone, cefotetan, drugs affecting platelet function (including abciximab, clopidogrel, eptifibatide, ticlopidine, tirofiban), plicamycin, thrombolytics, valproic acid, warfarin: increased risk of bleeding

Cyclosporine: increased risk of nephrotoxicity

Digoxin: slightly increased digoxin blood level

Lithium: increased lithium blood level, greater risk of lithium toxicity

Methotrexate: increased risk of methotrexate toxicity

Probenecid: increased risk of ibuprofen toxicity

Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, blood urea nitrogen, creatinine, lactate dehydrogenase, potassium: increased values

Bleeding time: prolonged

Creatinine clearance, glucose, hematocrit, hemoglobin, platelets, white blood cells: decreased values

Drug-herbs.Anise, arnica, chamomile, clove, dong quai, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, licorice: increased risk of bleeding

White willow: additive adverse GI effects

Drug-behaviors.Alcohol use: additive adverse GI effects

Sun exposure: phototoxicity

Patient monitoring

• Monitor for desired effect.
• Watch for GI upset, adverse CNS effects (such as headache and drowsiness), and hypersensitivity reaction.
• Stay alert for GI bleeding and ulcers, especially in long-term therapy.
• In long-term therapy, assess renal and hepatic function regularly.
• Monitor blood pressure closely during treatment.

Patient teaching

• Tell patient to take oral drug with full glass of water, with food, or after meals to minimize GI upset.
• To help prevent esophageal irritation, instruct patient to avoid lying down for 30 to 60 minutes after taking dose.

Instruct patient to immediately report irregular heartbeats, black tarry stools, vision changes, unusual tiredness, yellowing of skin or eyes, change in urination pattern, difficulty breathing, finger or ankle swelling, weight gain, itching, rash, fever, or sore throat.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, alertness, and balance.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

Brufen

A brand name for IBUPROFEN.

ibuprofen

; Brufen anti-inflammatory, analgesic and antipyretic non-steroidal anti-inflammatory drug (NSAID); fewer side-effects than other non-selective NSAIDs, but has weaker anti-inflammatory properties; adult dose = 1.6-2.4 g daily (for arthritic and musculoskeletal pain); inappropriate for inflammatory conditions (e.g. acute gout); see non-steroidal anti-inflammatory drugs; Table 1
Table 1: The range of side-effects of long-term non-steroidal anti- inflammatory drug (NSAID) medication
SystemEffect
GastrointestinalNausea; dyspepsia; diarrhoea; peptic ulceration or perforation; bleeding
RenalFluid retention; peripheral oedema; renal failure; papillary necrosis; interstitial fibrosis
RespiratoryBronchoconstriction; pulmonary eosinophilia; alveolitis
CoagulationReduced platelet aggregation; increased bleeding time; easy bruising
SkinSevere allergic reactions (e.g. Stevens-Johnson syndrome); toxic epidermal necrolysis; angioedema; skin thinning; reduced healing
VisceralCongestive heart failure; hepatitis; pancreatitis; aseptic meningitis
References in periodicals archive ?
We have contacted the manufacturer of Brufen to confirm the inaccuracy of these rumours," he added.
Brufen Tablets, containing 200mg, 400mg or 600mg of Ibuprofen and with analgesic and anti-inflammatory effects, are used in the treatment of rheumatoid arthritis, dental pain and headaches.
Quotations are invited for Supply of Tab Andial 2 mg, Tab Cetrizine, Tab sthalin, Tab Avil 25 mg, Tab Brufen 400 mg, Tab Buscopan 10 mg, Tab Combiflam,Tab Deriphylline, Tab Disprin, Tab Draminate 50 mg, Tab Vertine 16 mg, Tab Envas 2.
Formulated by ISSP in collaboration with the Brufen Foundation, the protocol and guidelines are formulated to help doctors in providing a welldefined sequence of diagnostic investigations and the line of treatment for specific conditions associated with acute or chronic pain.
I'VE stopped my daily Brufen tablets, and now my legs are so stiff.
The prescription slip listed three drugs, Brufen, Rantac and Voveron.
scabome 450ml, Tab celin 500 (vit c), Tab brufen 200mg (ibufren), Tab flagyl 400, tab cefadroxil 500, tab cefadroxil kit 125.
Drugs such as asprin, brufen, nimusilide should be avoided because they alter the blood clotting and platelet functions.
Only two patients having moderate pain were given tab brufen 400 mg thrice a day empirically to avoid the unrest.
The risk for this overdose is highest with drugs that function by depressing the central nervous system, which include painkillers such as Brufen, anti allergy drugs like cetirizine and sedatives such as Valium.