Brovana

arformoterol

(al-fer-mo-te-rol) ,

Brovana

(trade name)

Classification

Therapeutic: bronchodilators
Pharmacologic: adrenergics
Pregnancy Category: C

Indications

Maintenance treatment to prevent bronchospasm in chronic obstructive pulmonary disease (COPD) including chronic bronchitis and emphysema.

Action

Produces accumulation of cyclic adenosine monophosphate (cAMP) at beta-adrenergic receptors, resulting in relaxation of airway smooth muscle. Relatively specific for beta2 (pulmonary) receptors.

Therapeutic effects

bronchodilation.

Pharmacokinetics

Absorption: Some systemic absorption occurs from pulmonary sites.
Distribution: Unknown.
Metabolism and Excretion: Mostly metabolized by the liver; 1% excreted unchanged in urine.
Half-life: 26 hr.

Time/action profile

ROUTEONSETPEAKDURATION
inhalnunknown30 min12 hr

Contraindications/Precautions

Contraindicated in: Hypersensitivity; Acutely deteriorating COPD (onset of action is delayed); Pediatric: Safety not established; Concurrent use of other long-acting beta2 agonist bronchodilators.
Use Cautiously in: Cardiovascular disorders including coronary insufficiency, arrhythmias and hypertension; Hepatic impairment; Geriatric: May be more sensitive to drug effects; Obstetric / Lactation: Safety not established; use only when maternal benefit outweighs fetal risk, may inhibit contractions during labor.

Adverse Reactions/Side Effects

Central nervous system

  • headache
  • insomnia
  • nervousness
  • weakness

Respiratory

  • asthma-related death (life-threatening)
  • paradoxical bronchospasm (life-threatening)

Cardiovascular

  • ECG changes
  • tachycardia

Gastrointestinal

  • vomiting

Dermatologic

  • rash

Fluid and Electrolyte

  • hypokalemia

Hematologic

  • leukocytosis

Musculoskeletal

  • cramps

Neurologic

  • tremor

Miscellaneous

  • hypersensitivity reactions including anaphylaxis
  • fever

Interactions

Drug-Drug interaction

Concurrent use with MAO inhibitors, tricyclic antidepressants or other agents that may prolong the QTc interval may result in serious arrhythmias and should be undertaken with extreme caution.↑ risk of hypokalemia with theophylline, corticosteroids, potassium-losing diuretics.Beta blockers may ↓ therapeutic effects.↑ adrenergic effects may occur with concurrent use of adrenergics.

Route/Dosage

Inhalation (Adults) 15 mcg twice daily via nebulization.

Availability

Inhalation solution for nebulization: 15 mcg/2 mL

Nursing implications

Nursing assessment

  • Assess lung sounds, pulse, and BP before administration and periodically during therapy.
  • Monitor pulmonary function tests before initiating therapy and periodically during therapy to determine effectiveness of medication.
  • Observe for paradoxical bronchospasm (wheezing, dyspnea, tightness in chest) and hypersensitivity reaction (rash; urticaria; swelling of the face, lips, or eyelids). If condition occurs, withhold medication and notify physician or other health care professional immediately.

Potential Nursing Diagnoses

Ineffective airway clearance (Indications)

Implementation

  • Inhalation: Administer twice daily, approximately 12 hrs apart. Solution is colorless; do not administer discolored solutions. Do not administer beyond expiration date. Do not mix with other drugs in nebulizer. Administer by inhalation only; do not inject or swallow medication.

Patient/Family Teaching

  • Instruct patient on proper technique use and advise patient to take arformoterol as directed. Do not use more than the prescribed dose. If a regularly scheduled dose is missed, skip the dose and resume regular schedule. Do not double doses. If symptoms occur before next dose is due, use a rapid-acting inhaled bronchodilator (e.g. albuterol). See for nebulizer instructions.
  • Inform patient that arformoterol may increase the risk of asthma-related death.
  • Advise patients who have been taking short-acting beta2 agonists regularly to discontinue regular use and use only for symptomatic relief of acute respiratory symptoms.
  • Caution patient not to use arformoterol to treat acute symptoms. A rapid-acting inhaled beta-adrenergic bronchodilator should be kept on hand and used for relief of acute asthma attacks.
  • Advise patient to notify health care professional immediately if difficulty in breathing persists after use of arformoterol, if condition worsens, if more inhalations of rapid-acting bronchodilator than usual are needed to relieve an acute attack.
  • Advise female patients to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

  • Decreased dyspnea.
  • Improved breath sounds.

Brovana

a trademark for arformoterol.
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References in periodicals archive ?
Our study forecasts revenues for 27 therapies including 5 promising pipeline candidates: - Ventolin - ProAir - Proventil - Xopenex - Foradil - Serevent - Arcapta/Onbrez - Brovana - Spiriva - Atrovent - Eklira/Tudorza/Bretaris - Flixotide/Flovent - Pulmicort - QVAR - Asmanex - Singulair - Xolair - Cinquil - Mepolizumab - Benralizumab - Lebrikizumab - Dupilumab - Advair/Seretide - Symbicort - Combivent - Dulera - Breo/Relvar ElliptaSee revenue forecasts for the leading international markets How will leading national markets perform to 2025?
Xopenex -- Foradil -- Serevent -- Arcapta/Onbrez -- Brovana -- Spiriva -- Atrovent -- Eklira/Tudorza/Bretaris -- Flixotide/Flovent -- Pulmicort -- QVAR -- Asmanex -- Singulair -- Xolair -- Cinquil -- Mepolizumab -- Benralizumab -- Lebrikizumab -- Dupilumab -- Advair/Seretide -- Symbicort -- Combivent -- Dulera -- Breo/Relvar Ellipta
Dey is currently pursuing a patent infringement lawsuit against Sepracor relating to its Brovana product.
Brovana, an inhaled drug launched last April for people with chronic obstructive pulmonary disease, brought in $6.
Arformoterol is the single, (R,R)-isomer form of racemic formoterol, which is approved by the FDA as Brovana for maintenance treatment of COPD.
said its drug Brovana has received a specific billing code from the federal government's Centers for Medicare and Medicaid Services, a step in the new drug's market acceptance.
Mode of Action 51 Approvals 51 Lifecycle Development 51 Patents 52 Generic Company Activity 52 Market Outlook 52 Brovana (arformoterol tartrate) 54 Mode of Action 54 Approvals 54 Patents 54 Patent Infringement Litigation 55 Generic Company Activity 55 Market Outlook 55 Onbrez Breezhaler/Arcapta Neohaler (indacaterol) 57 Mode of Action 57 Approvals 57 Patents 57 Market Outlook 58 ALLERGIC RHINITIS 59 Market Overview 59 Market Leaders 59 New Products to Watch 60 Approved Generics 61 Nasonex (mometasone furoate) 63 Mode of Action 63 Approvals 63 Patents 63 Generic Company Activity 64 Sandoz 64
Sales of Brovana, a drug introduced in April for people with chronic obstructive pulmonary disease, hit $2.
LUNESTA, XOPENEX, XOPENEX HFA and BROVANA are registered trademarks of Sunovion Pharmaceuticals Inc.
Sepracor said in a filing with the Securities and Exchange Commission that Dey alleges Sepracor's Brovana drug infringes on Dey's single U.
Further, the Order states that Sunovion's Brovana product infringes each of those patents.