Bronchodilators


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Bronchodilators

 

Definition

Bronchodilators are medicines that help open the bronchial tubes (airways) of the lungs, allowing more air to flow through them.

Purpose

People with asthma have trouble breathing, because their airways are inflamed and become narrowed. Normally, air moves smoothly from the mouth and nose through the airways and into the tiny air sacs of the lungs as a person breathes in. Breathing out (exhaling) happens automatically when the person stops breathing in. In a person with asthma, breathing in (inhaling) is not a problem. Incoming air can slide around the blockage, because the act of breathing in makes the airways expand. The problem comes when the person with asthma tries to breathe out. The air can no longer get past the blockage, and it remains trapped in the lungs. The person can then only take shallow breaths. Bronchodilators work by relaxing the smooth muscles that line the airways. This makes the airways open wider and allows air to leave the lungs. These drugs also are used to relieve breathing problems associated with emphysema, chronic bronchitis, and other lung diseases.

Description

Some bronchodilators are inhaled, using a nebulizer or an inhalation aerosol. Others are taken as injections or by mouth. Most are available only by prescription, but a few, such as ephedrine, can be bought without a physician's prescription. Examples of bronchodilators are albuterol (Proventil, Ventolin), epinephrine (Primatene), ipratropium (Atrovent), metaproterenol (Alupent, Metaprel), and terbutaline (Brethine).

Recommended dosage

The recommended dosage depends on the type of bronchodilator and may be different for different patients. The physician who prescribed the drug or the pharmacist who filled the prescription can recommend correct dosage.

Precautions

Bronchodilators come with patient instructions that must be carefully read before using the medicine. If there is any confusion about how to use the medicine, patients should check with the physician or pharmacist. These medicines must be used exactly as directed. Taking larger than recommended doses or using the medicine too often can lead to serious side effects and even death.
If symptoms do not improve or if they get worse after using a bronchodilator, the patient should call a physician right away.
Although some bronchodilators are available without a physician's prescription, these medicines should not be used unless a physician has diagnosed the patient's condition as asthma.
Research shows that frequent bronchodilator use over time can tighten airway muscles in some people. Some physicians advise patients to consider controlling asthma with anti-inflammatory drugs including inhaled steroids such as beclomethasone dipropionate (Beclovent, Vanceril), flunisolide (AeroBid) or triamcinolone acetonide (Azmacort). A 2004 Canadian study has questioned a standard practice of increasing steroids after asthma attacks or worsened symptoms. Also, research in 2004 showed that people with asthma who worked closely with their physicians to self-manage their asthma had fewer attacks, which reduces the need for bronchodilators. Carefully managing asthma also reduces visits to the emergency department and hospitalizations.

Key terms

Anti-inflammatory — Medicine used to relieve swelling, pain, and other symptoms of inflammation.
Bronchitis — Inflammation of the air passages of the lungs.
Chronic — A word used to describe a long-lasting condition. Chronic conditions often develop gradually and involve slow changes.
Emphysema — A lung disease in which breathing becomes difficult.
Inflammation — Pain, redness, swelling, and heat that usually develop in response to injury or illness.
Nebulizer — A device that turns liquid forms of medicine into a fine spray that can be inhaled.
Sulfite — A type of preservative that causes allergic reactions in some people.
Persons with diabetes should be aware that the bronchodilator epinephrine may raise their blood sugar levels.
Patients who are using an aerosol bronchodilator and an aerosol form of either ipratropium or a corticosteroid such as beclomethasone dipropionate (Beclovent, Vanceril) should use the bronchodilator first, then wait 5 minutes before using the other medicine. A physician should be consulted before using any other inhaled medications or other asthma medicines. The physician must determine the proper amount of time between doses.
Some bronchodilator products contain sulfites that trigger an allergic reaction in certain people. Anyone who has a sulfite allergy should read the label carefully or check with a physician or pharmacist before using a bronchodilator. Call a physician immediately if any of these signs of an allergic reaction to sulfite occur:
  • bluish coloration of the skin
  • flushed or red face or skin
  • faintness
  • severe dizziness
  • increased wheezing or other breathing problems
  • skin rash, hives, or itching
  • swelling of the face, lips, or eyelids

Special conditions

People with certain medical conditions or who are taking certain other medicines can have problems if they use bronchodilators. Before using these drugs, a physician should be made aware of any of these conditions:
ALLERGIES. Anyone who has had unusual reactions to any bronchodilator or an inhaled form of any other drug in the past should let his or her physician know before taking the drugs again. The physician should also be told about any allergies to foods, dyes, preservatives, or other substances.
Patients who are allergic to soybeans, soy lecithin, peanuts, or drugs based on atropine should not use the bronchodilator ipratropium (Atrovent).
PREGNANCY. In studies of laboratory animals, some bronchodilators cause birth defects or miscarriage when the animals are given doses many times the usual human dose. Whether these drugs cause such problems in humans in unknown. Any woman who is pregnant or plans to become pregnant should check with her physician before using a bronchodilator.
BREASTFEEDING. Some bronchodilators pass into breast milk. Breastfeeding mothers should check with their physicians before using bronchodilators.
OTHER MEDICAL CONDITIONS. Before using bronchodilators, people with any of these medical problems should make sure their physicians are aware of their conditions:
  • glaucoma
  • brain damage
  • convulsions (seizures)—recently or anytime in the past
  • mental illness
  • parkinson's disease
  • diabetes
  • heart or blood vessel diseases
  • rapid or irregular heartbeat
  • high blood pressure
  • overactive thyroid
  • enlarged prostate
  • obstruction of the neck of the bladder
USE OF CERTAIN MEDICINES. Using bronchodilators with certain other drugs may affect the way the drugs work or may increase the chance of side effects.

Side effects

Some patients have a dry or irritated throat or a dry mouth after using bronchodilators. To help prevent these problems, gargling and rinsing the mouth or taking a sip of water after each dose.
The most common side effects are nervousness or restlessness and trembling. These problems usually go away as the body adjusts to the drug and do not require medical treatment. Less common side effects, such as bad taste in the mouth, coughing, dizziness or lightheadedness, drowsiness, headache, sweating, fast or pounding heartbeat, muscle cramps or twitches, nausea, vomiting, diarrhea, sleep problems and weakness also may occur and do not need medical attention unless they do not go away or they interfere with normal activities.
More serious side effects are not common, but may occur. If any of the following side effects occur, the physician who prescribed the medicine should be contacted as soon as possible:
  • chest pain or discomfort
  • irregular or fluttery heartbeat
  • unusual bruising
  • hives or rash
  • swelling
  • wheezing or other breathing problems
  • numbness in the hands or feet
  • blurred vision
Other side effects are possible. Anyone who has unusual symptoms after using a bronchodilator should get in touch with his or her physician.

Interactions

Bronchodilators may interact with a number of other medicines. When this happens, the effects of one or both of the drugs may change or the risk of side effects may be greater. Anyone who takes these drugs should let the physician know all other medicines he or she is taking. Among the drugs that may interact with bronchodilators are:
  • monoamine oxidase inhibitors (MAO inhibitors) such as phenelzine (Nardil) and tranylcypromine (Parnate), used to treat depression
  • other bronchodilators
  • tricyclic antidepressants such as amitriptyline (Elavil) and imipramine (Tofranil)
  • beta blockers such as propranolol (Inderal) and atenolol (Tenormin), used to control high blood pressure
  • digitalis medicines, used to treat heart conditions, such as digoxin (Lanoxin)
  • drugs, such as certain diuretics (water pills), that lower potassium levels
  • ergoloid mesylates such as Hydergine, used to treat symptoms of Alzheimer's disease or multiple small stokes
  • ergotamine (Cafergot, Ergostat, and other brands), used to treat migraine and cluster headaches
  • the antidepressant maprotiline (Ludiomil).
The list above does not include every drug that may interact with bronchodilators. Be sure to check with a physician or pharmacist before combining bronchodilators with any other prescription or non-prescription (over-the-counter) medicine.

Resources

Periodicals

"Study Calls Standard Asthma Management Into Doubt." Doctor July 15, 2004: 4.
"What's New in: Asthma and Allergic Rhinitis." Pulse September 20, 2004: 50.
"Wheezing? Check Your Inhaler." Prevention September 2004: 34.

Organizations

American Academy of Allergy, Asthma, and Immunology. 611 East Wells St., Milwaukee, WI 53202. (800) 822-2762. http://www.aaaai.org.
Asthma and Allergy Foundation of America. 1233 20th Street, NW, Suite 402, Washington, DC 20036. (800) 727-8462. http://www.aafa.org.
National Heart, Lung and Blood Institute. P.O. Box 30105, Bethesda, MD 20824-0105. (301) 251-1222. http://www.nhlbi.nih.gov.
References in periodicals archive ?
Pearl is rapidly advancing a pipeline of products including PT003, an inhaled, fixed-dose combination bronchodilator product comprised of a long-acting muscarinic antagonist (LAMA) and a long-acting beta-2 agonist (LABA) delivered via a metered dose inhaler (HFA MDI); and PT010, a triple-combination product that combines the LAMA and LABA components of PT003 with an inhaled corticosteroid (ICS) for twice-daily administration from an HFA MDI for the treatment of severe COPD.
In patients with mild asthma, a rapid, potent and long-lasting bronchodilator response was produced.
The nebulised bronchodilator market was worth approximately $1 billion in 2014 in the US.
Provides market data and forecasts for orally inhaled bronchodilators to 2022
Epinephrine is a short-acting beta2-agonist bronchodilator.
However, the lack of an association between orofacial clefts and bronchodilators among those women who also used an anti-inflammatory drug suggests that perhaps women on polytherapy had more optimum treatment and therefore better control.
These compounds represent a new class of bronchodilator that work through an entirely different mechanism than beta-agonists like albuterol, salmeterol and formoterol," added Robinett.
The FDA has recently made several changes and additions to adrenergic bronchodilators.
In mild stages, smoking cessation and intermittent use of short acting bronchodilators are needed to reduce symptoms and improve prognosis.
Bronchodilators are used as first-line agents for the symptomatic treatment of patients with COPD.
We use an individual-level, fixed-effects model to estimate the unbiased effects of adding ICS treatment on monthly medical expenses and likelihood of severe exacerbations among COPD patients who were initially under treatment with regular bronchodilators.
Asthma medications called bronchodilators are typically designed to be short-acting--they act quickly to stop an asthma attack once it has started by relaxing and opening--"dilating"--the bronchial tubes so more air is available.