Exposure to IR/and or PQ induced degenerative changes in the bronchiolar epithelium
identified by the presence of fragments of cells and small dark nuclei, thickened edematous bronchiolar walls infiltrated with round cells, some small muscular arterioles showed medial hypertrophy in the presence of focal alveolar emphysema (Fig.
However, in most patients with folded bronchiolar epithelium
there is no airway obstruction, except in airway-related diseases such as asthma and constrictive bronchiolitis, where other characteristics (increased luminal mucus, inflammation, thickened basement membrane, and/or fibrosis) explain the obstruction.
Differentiated bronchiolar epithelium
in alveolar ducts of rats exposed to ozone for 20 months.
Attachment was negative for tracheal and bronchial epithelium, scarce for bronchiolar epithelium
, and moderate for alveolar epithelium in cetaceans (Table, Figure).
cells known as Clara cells are thought to help defend airways against damage; Clara cell protein (CC16) is a lung-specific protein thought to protect the respiratory tract from inflammation.
Bronchiolar-type epithelium that grows along the alveolar surfaces adjacent to bronchioles has been termed peribronchiolar metaplasia or lambertosis, in reference to the canals of Lambert through which bronchiolar epithelium
was once considered to traverse to grow on alveolar septa (21,29,38-41) (Figures 3 and 4).
For the first time, staining of the bronchiolar epithelium
was also visible, but not all bronchioles--far from all, in fact--showed this staining.
Georges JA, Wilson DW, Dungworth DL Response of macaque bronchiolar epithelium
to ambient concentrations of ozone.
The abnormal stimulation of bronchial and bronchiolar epithelium
can lead to basal cell hyperplasia followed by either squamous metaplasia (characterized by maintenance of the basal cell phenotype) or goblet cell hyperplasia.
At 3, 6, and 9 dpi, large amounts of influenza A virus antigen were found in bronchial and bronchiolar epithelium
and lumens (Figure 3, panel F).
Immunohistochemical staining, with a polyclonal antibody (6), showed morbillivirus antigen in bronchiolar epithelium
, syncytial cells, monocyte-like cells, and cell debris of affected lymph nodes and brain; these tissues often showed a positive intracytoplasmic globular or granular immunoreaction.
Similarly, we did not find viral antigen in bronchiolar epithelium
in the lung sections.