terbutaline sulfate

(redirected from Brethair)

terbutaline sulfate

Monovent

Pharmacologic class: Selective beta2-adrenergic receptor agonist

Therapeutic class: Bronchodilator

Pregnancy risk category B

Action

Relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors; inhibits release of hypersensitivity mediators, especially from mast cells

Availability

Injection: 1 mg/ml

Tablets: 2.5 mg, 5 mg

Indications and dosages

Bronchospasm in reversible obstructive airway disease

Adults and children older than age 12: 0.25 mg subcutaneously, repeated in 15 to 30 minutes p.r.n., up to a maximum of 0.5 mg in 4 hours. Or 2.5 to 5 mg P.O. q 6 hours t.i.d. while awake, up to a maximum of 15 mg/day in adults; 2.5 mg P.O. q 6 hours t.i.d. while awake, up to a maximum of 7.5 mg/day in children.

Dosage adjustment

• Renal impairment

Off-label uses

• Tocolytic in preterm labor

Contraindications

• Hypersensitivity to drug, its components, or sympathomimetic amines

Precautions

Use cautiously in:
• cardiovascular disorders, hypertension, arrhythmias, hyperthyroidism, diabetes mellitus, seizure disorders, glaucoma
• concurrent use of MAO inhibitors, tricyclic antidepressants, or beta-adrenergic blockers
• elderly patients
• breastfeeding patients.

Administration

• Inject subcutaneously into lateral deltoid.

Adverse reactions

CNS: tremors, anxiety, nervousness, insomnia, headache, dizziness, drowsiness, stimulation

CV: palpitations, chest discomfort, tachycardia

GI: nausea, vomiting

Skin: diaphoresis, flushing

Interactions

Drug-drug. Beta-adrenergic blockers: blockage of bronchodilating effect

MAO inhibitors, tricyclic antidepressants: potentiation of terbutaline's adverse cardiovascular reactions

Other sympathomimetic amines: additive adverse cardiovascular reactions

Patient monitoring

• Monitor vital signs.
• Assess neurologic status.

Patient teaching

• Tell patient he may take with or without food.
• Advise patient or parents to establish effective bedtime routine to minimize insomnia.
• Instruct patient or parents to space doses evenly during waking hours, to avoid taking drug at bedtime.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

terbutaline sulfate

[terbyo̅o̅′təlēn]
a beta2-adrenergic stimulant.
indications It is prescribed as a bronchodilator in the treatment of asthma, bronchitis, and emphysema and as a uterine relaxant to treat premature labor.
contraindications Cardiac arrhythmias or known hypersensitivity to this drug prohibits its use. Toxicity is increased by monoamine oxidase inhibitors and tricyclic antidepressants, and beta-adrenergic blocker effects are decreased.
adverse effects Among the most serious effects are dizziness and palpitations. Nervousness and tremor are common reactions.

Bricanyl

A beta-adrenergic receptor agonist used for patients with COPD.
 
Indications
Asthma, bronchitis, reversible bronchospasm.
 
Adverse effects
Tremor, nervousness, palpitations, nausea, vomiting.

terbutaline sulfate (terbū´təlēn´),

n brand names: Brethaire, Brethine, Bricanyl;
drug class: selective β2-agonist;
action: relaxes bronchial smooth muscle by direct action on β2-adrenergic receptors;
uses: bronchospasm, asthma prophylaxis, premature labor inhibitor.