Breslow thickness

Bres·low thick·ness

(bres'lō),
maximal thickness of a primary cutaneous melanoma measured in tissue sections from the top of the epidermal granular layer, or from the ulcer base (if the tumor is ulcerated), to the bottom of the tumor; metastatic rates correlate closely with tumor thickness.

Breslow thickness

The greatest thickness of a primary cutaneous melanoma, measured in millimeters in a biopsy specimen from the granular layer of the epidermis down to the deepest point of invasion. Thickness is part of the TNM staging of melanoma and is also used as a prognostic factor. In general, the thicker the lesion the worse the prognosis. See cancer staging.

Bres·low thick·ness

(brez'lō thik'nĕs)
Maximal thickness of a primary cutaneous melanoma measured in tissue sections from the top of the epidermal granular layer, or from the ulcer base (if the tumor is ulcerated), to the bottom of the tumor; metastatic rates correlate closely with tumor thickness.

Breslow,

Alexander, U.S. pathologist, 1928-1980.
Breslow thickness - maximal thickness of a primary cutaneous melanoma.
References in periodicals archive ?
Among women with melanoma, mole count did not predict Breslow thickness.
Of the histological features of primary cutaneous melanoma Breslow thickness is the strongest predictor of survival.
81) was not associated with melanoma-specific mortality after adjusting for Breslow thickness (mm), stage at diagnosis, and age at diagnosis.
The lesions tend to have higher Breslow thickness, advanced nodal stage and over-all stage, and more ulceration.
Superior survival of females among 10,538 Dutch melanoma patients is independent of Breslow thickness, histologic type and tumor site.
13) Furthermore, mucosal desmoplastic melanoma lesions are usually thicker than cutaneous desmoplastic melanoma lesions, and studies have shown that a Breslow thickness greater than 4 mm correlates with a local recurrence rate of 40.
The Clark levels were determined, in 131 cases the Breslow thickness of the tumour was measured, and the presence or absence of ulceration was recorded.
For example, in a prospective cohort study involving 872 melanoma patients in the United Kingdom, investigators found that higher serum vitamin D levels at diagnosis were associated with a thinner tumor Breslow thickness and also--independent of Breslow thickness--with better survival (J.
In more advanced cases, the excision margins depend on the Breslow thickness (varies from 2 to 4 cm).
2,9) The single most important and accurate prognostic factor is the depth of invasion of the tumor as measured by Breslow thickness.
Histopathology reports were reviewed for patients' geographical area, gender, age, ethnic group, tumour site, Clark level of invasion, Breslow thickness (mm), and histogenetic type (when available).
A man had undergone a wide local excision and an isolated limb perfusion for a primary melanoma on his right leg in the mid-1970s; the Breslow thickness is unknown.