81) was not associated with melanoma-specific mortality after adjusting for Breslow thickness
(mm), stage at diagnosis, and age at diagnosis.
The lesions tend to have higher Breslow thickness
, advanced nodal stage and over-all stage, and more ulceration.
13) Furthermore, mucosal desmoplastic melanoma lesions are usually thicker than cutaneous desmoplastic melanoma lesions, and studies have shown that a Breslow thickness
greater than 4 mm correlates with a local recurrence rate of 40.
In more advanced cases, the excision margins depend on the Breslow thickness
(varies from 2 to 4 cm).
Histopathology reports were reviewed for patients' geographical area, gender, age, ethnic group, tumour site, Clark level of invasion, Breslow thickness
(mm), and histogenetic type (when available).
A man had undergone a wide local excision and an isolated limb perfusion for a primary melanoma on his right leg in the mid-1970s; the Breslow thickness
The Breslow thickness
is measured from the top of the epidermal granular layer to the deepest melanocyte of the invasive component of melanoma.
melanoma patients, investigators found that higher serum vitamin D levels at diagnosis were associated with a thinner tumor Breslow thickness
and also--independent of Breslow thickness
--with better survival (J.
5) The Breslow thickness
is determined by measuring from the top of the granular layer of the overlying skin, or from the base of an overlying ulcer, to the deepest invasive melanoma cell.
Sentinel node biopsy (SNB) is recommended for patients whose tumors have a Breslow thickness
of greater than 1 mm and for those whose tumors are thinner but have adverse features, such as ulceration or a Clark level of IV or V Currently, it is done to obtain prognostic information and identify the roughly 20% of patients who may benefit from a complete lymph node dissection, Dr.
Regarding the histologic factors with prognostic relevance in CMC, we encourage the use of the same criteria as for melanoma in adults--clinicopathologic type, Breslow thickness
, Clark level, radial and vertical growth phase, and ulceration (52)--to investigate if, in children, they are also predictive of biologic behavior.
In a multivariate Cox regression analysis, tumor Breslow thickness
, ulceration, patient gender, and SLN status were independent predictors of both overall and disease-free survival.