Breslow's thickness

Breslow's thickness

system of measurement predictive of melanoma prognosis; i.e. <0.75 mm thick = good prognosis, >0.75 mm thick = less favourable prognosis (see Table 1)
Table 1: Clarke's levels, denoting the level of invasion of a skin tumour
LevelFeature
ILesion confined to epidermis (i.e. in situ)
IIEpidermal lesion has just invaded into upper dermis
IIIEpidermal lesion has significantly invaded upper dermis
IVEpidermal lesion has invaded as far as deeper reticular dermis
VEpidermal lesion has invaded through dermis into subcuticular tissues

The greater the depth of lesion penetration, the more liable it is to undergo metastasis.

References in periodicals archive ?
Most authors seem to agree that several clinical and pathological characteristics such as age, sex, tumor localization, Breslow's thickness, ulceration, mitotic count, vessel invasion and the presence of tumor infiltrating lymphocytes are independent prognostic factors for relapse and overall survival of the patients with skin melanoma [1-7].
The features routinely examined included Breslow's thickness (measured in millimeters), Clark level, the presence or absence of ulceration and histological type.
This comparison confirmed the tumor characteristics, Breslow's thickness and lymphocyte response to be significantly different in patients with metastases in the regional lymph nodes, (Breslow's thickness p = 0.
Breslow's thickness significantly correlated with positive SLN status (p = 0.
Breslow's thickness remained the predictive factor of positive SNL status.
Also the 5-year DFS was better for patients with Breslow's thickness [less than or equal to] 4mm (37.
The current study has identified Breslow's thickness and lymphocytic response as independent predictors of SLN status for cutaneous melanoma patients.
According to the literature, Breslow's thickness, as the most important independent predictor for SLN status, is regularly used to identify patients for sentinel node biopsy [8].
This comparison demonstrated that Breslow's thickness and lymphocyte response were significantly different between the two groups and confirmed their prognostic value.
9% of the SLN + patients in our study were with thick melanomas ([greater than or equal to] 4 mm), while Breslow's thickness was <4 mm in 57.
Despite the limitation of this study, we have identified two factors predictive of sentinel lymph node metastasis in cutaneous melanoma patients in our country, which are Breslow's thickness and tumor lymphocytic infiltration.