brachyury


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brachyury

An embryonic nuclear transcription factor encoded by T gene within the T-box complex of genes on chromosome 6q27, which binds to the palindromic T site on DNA. Brachyury effects transcription of genes required for mesoderm formation and differentiation, mediates epithelial-mesenchymal transition and is localised to notochord-derived cells.

Molecular pathology
Brachyury is the definitive diagnostic marker of chordoma, a malignancy arising from remnant notochordal cells in the vertebrae; germline duplication of brachyury confers susceptibility to chordoma. It is overexpressed in various cancers and promotes invasion.

brachyury

shortness of the tail, as in some Manx cats.
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Summary of 58 Nonchordomatous Tumors Also Evaluated for Brachyury Expression Case Age, No.
Lately, gene expression analysis has unraveled a key nuclear transcription factor, brachyury or T as a specific marker for chordoma.
Brachyury staining was performed in all 51 chordomas (Table 1).
Wesley Hsu, MD, Wake Forest University Health Sciences Inhibition of FGFR1/MAPK signaling to downregulate brachyury for the treatment of lung cancer
A prominent example of this coordination is found in the gastrulation of amniotes, where Brachyury (Bra), a transcription factor, is synchronously and transiently expressed in a localized population, the Primitive Streak (PS).
Spermatogonial stem cell self-renewal requires ETV5-mediated downstream activation of Brachyury in mice.
Upcoming research will focus on understanding why the alteration in brachyury is so critical for chordoma development and what other factors are at play.
The research team is currently poised to launch the next phase of the Chordoma Genome Project, which will attempt to determine what actually triggers the development of chordoma once the brachyury variation creates the predisposition.
42-44) Recently, inhibin A, D240, and brachyury have been found to be present in hemangioblastomas and may be helpful in differentiating them from other CCTs.
Expression of brachyury in hemangioblastoma: potential use in differential diagnosis [published online ahead of print March 25, 2012].
molecular basis for the structural asymmetry of the body has been linked to a complex interaction of fibroblast growth factor 8, Nodal gene, Lefty 2 gene, PITX2 gene, Lefty 1 gene, Sonic HedgeHog (SHH) gene, Brachyury (T) gene and expression of Snail transcription factor [7].
Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis.