Braak staging

Braak staging

A system formulated in 1991 by Drs. Braak and Braak (Acta Neuropathologica Berl—82:239-259) for staging the severity of Alzheimer’s disease (AD), based on the premise that AD pathology—specifically neurofibrillary tangles—evolve in stages and locations, beginning in the mesial temporal lobe (stages 1 and 2) and extending to the limbic regions (stages 3 and 4)—at which point dementia manifests itself clinically—ending in the neocortex (stages 5 and 6).
References in periodicals archive ?
A critical evaluation of the Braak staging scheme for Parkinson's disease.
8 In contrast, Braak staging correlates well with clinical dementia but does not adequately address the contribution of amyloid/plaque pathology to some cases of AD, particularly familial forms.
Braak staging of neurofibrillary spread was also performed.
A system called Braak staging has been devised that correlates the pattern of spread of tau protein pathology with disease severity.