Braak staging

Braak staging

A system formulated in 1991 by Drs. Braak and Braak (Acta Neuropathologica Berl—82:239-259) for staging the severity of Alzheimer’s disease (AD), based on the premise that AD pathology—specifically neurofibrillary tangles—evolve in stages and locations, beginning in the mesial temporal lobe (stages 1 and 2) and extending to the limbic regions (stages 3 and 4)—at which point dementia manifests itself clinically—ending in the neocortex (stages 5 and 6).
References in periodicals archive ?
115] This highlights the value of tau tracers during in vivo Braak staging and suggests that tau pathology in regions beyond the medial temporal lobe may be strong indicators for advanced AD onset.
This was consistent with Braak stage V/VI, which was confirmed by our in vivo Braak staging," they added.
We demonstrated the presence of anatomical profiles of increased 18F-AVT451 binding that strongly mirrored the stereotypical spread and progression of tau pathology that is encapsulated in the Braak staging scheme," the researchers concluded.
A critical evaluation of the Braak staging scheme for Parkinson's disease.
8 In contrast, Braak staging correlates well with clinical dementia but does not adequately address the contribution of amyloid/plaque pathology to some cases of AD, particularly familial forms.
Braak staging of neurofibrillary spread was also performed.
A system called Braak staging has been devised that correlates the pattern of spread of tau protein pathology with disease severity.