aprotinin

(redirected from Bovine pancreatic trypsin inhibitor)
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Related to Bovine pancreatic trypsin inhibitor: Leupeptin, Pancreatic Secretory Trypsin Inhibitor

aprotinin

 [ap″ro-ti´nin]
an inhibitor of proteolytic enzymes, used as an antihemorrhagic to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass during coronary artery bypass graft; administered intravenously.

aprotinin

/apro·ti·nin/ (ap″ro-ti´nin) an inhibitor of proteolytic enzymes used to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass during coronary artery bypass graft.

aprotinin

(ā-prōt′n-ĭn, ă-prōt′-)
n.
A polypeptide obtained from bovine lungs that is a protease inhibitor and has been used to reduce bleeding in patients undergoing cardiopulmonary bypass surgery. It was largely withdrawn from the market in 2007 because of safety concerns.

aprotinin

[ap′ro-ti′nin]
an inhibitor of proteolytic enzymes, used as an antihemorrhagic to reduce perioperative blood loss in patients undergoing cardiopulmonary bypass during coronary artery bypass graft; administered intravenously.

aprotinin

A bovine polypeptide and protease inhibitor with antifibrinolytic activity that derives from basic pancreatic trypsin inhibitor (BPTI), which was added to fibrinogen in “fibrin glue”, theoretically enhancing the persistence of the fibrin clot.

It was pulled from the international market in 2007, given the concern that aprotinin increased the risk of complications and death during surgery. In 2012 the European Medicines Agency concluded that the benefits outweighed the risks, and recommended the suspension be lifted.

aprotinin

A drug used in the treatment of bleeding resulting from the excessive breakdown of the fibrin that forms blood clots. An antifibrinolytic. A brand name is Trasylol. In September 2006 the FDA issued a warning that this drug could cause renal failure, congestive heart failure, stroke and death.

aprotinin (āprō´tənin),

n a protease and kallikrein inhibitor useful in the treatment of pancreatitis.

aprotinin

a polyvalent kallikrein-trypsin inhibitor extracted from bovine mast cells; used therapeutically to inhibit fibrinolysis and in the laboratory as a preservative in plasma samples.
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