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Borna disease
(redirected from Bornaviridae)

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Borna disease
a geographically restricted virus disease of horses and occasionally sheep, characterized by a uniformly fatal encephalomyelitis. Clinically it is characterized by pharyngeal paralysis, muscle tremor, lethargy and flaccid paralysis. The causative virus is a non-segmented, negative-stranded RNA virus with a nuclear site of replication and transcription of its genome. It is noncytolytic and highly neurotropic and is the prototype and only member thus far identified of the family Bornaviridae, in the order Mononegavirales. Serologic evidence indicates that the host range of Borna disease virus or an antigenically related virus is wide and the virus has been linked to psychiatric illnesses in humans. Called also Near Eastern equine encephalomyelitis.
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As the prototype and only known member of the family Bornaviridae in the order Mononegavirales (nonsegmented, negative-strand RNA viruses), BDV is atypical in its nuclear localization of transcription, alternative splicing, and differential use of initiation and termination signals.
Novel Borna virus in Psittacine birds with proventricular dilatation ... by Honkavuori, Kirsi S.; Shivaprasad, H.L.; Williams, Brent L.; Quan, Phenix-Lan; Hornig, Mady; Street, / Emerging Infectious Diseases
The phylogeny identified clusters corresponding to the known families within the order: Rhabdoviridae, Paramyxoviridae, Filoviridae, and Bornaviridae.
Phylogeny of the mononegavirales and evolutionary divergence of the ... by Ledbetter, Kristen; Westover, Kristi M. / Bulletin of the South Carolina Academy of Science
Borna disease (BD) is a severe immunopathologic disorder of the central nervous system induced by infection with Borna disease virus (BDV), the prototype of a new virus family, Bornaviridae, within the order Mononegavirales.
Shrews as reservoir hosts of Borna disease virus by Ehrensperger, Felix / Emerging Infectious Diseases
 
 
 
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