Borna disease

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Related to Borna virus: encephalitis

Borna disease

An infectious encephalopathy of warm-blooded animals, including ruminants (e.g., cattle, horses, sheep), foxes, dogs, cats, birds and primates, which occurs in Central Europe, caused by the Borna virus.
 
Clinical findings
Motor and behavioural symptoms—aggression, eating disorders, hyperactivity, postural disorders, ataxia, disrupted social and sexual activity.
 
Epidemiology
Uncertain, probably via saliva or nasal secretions.

Mortality
Up to 100% in horses, 50% in sheep.

Borna disease

a geographically restricted virus disease of horses and occasionally sheep, characterized by a uniformly fatal encephalomyelitis. Clinically it is characterized by pharyngeal paralysis, muscle tremor, lethargy and flaccid paralysis. The causative virus is a non-segmented, negative-stranded RNA virus with a nuclear site of replication and transcription of its genome. It is noncytolytic and highly neurotropic and is the prototype and only member thus far identified of the family Bornaviridae, in the order Mononegavirales. Serologic evidence indicates that the host range of Borna disease virus or an antigenically related virus is wide and the virus has been linked to psychiatric illnesses in humans. Called also Near Eastern equine encephalomyelitis.
References in periodicals archive ?
The diagnosis of proventricular dilatation disease: use of a Western blot assay to detect antibodies against avian borna virus.
Depression is a very complex illness, involving among other things genetic factors and stress, to which the Borna virus has now been added as another probable player.
Earlier studies showed that the Borna virus has evolved over eons into distinct strains, each with a predilection for a specific animal species.
Furthermore, Borna virus antibodies have been reported in nearly one-third of people with certain mental illnesses, including obsessive-compulsive disorder and schizophrenia, he says.
Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain.