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Borna disease |
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Borna disease a geographically restricted virus disease of horses and occasionally sheep, characterized by a uniformly fatal encephalomyelitis. Clinically it is characterized by pharyngeal paralysis, muscle tremor, lethargy and flaccid paralysis. The causative virus is a non-segmented, negative-stranded RNA virus with a nuclear site of replication and transcription of its genome. It is noncytolytic and highly neurotropic and is the prototype and only member thus far identified of the family Bornaviridae, in the order Mononegavirales. Serologic evidence indicates that the host range of Borna disease virus or an antigenically related virus is wide and the virus has been linked to psychiatric illnesses in humans. Called also Near Eastern equine encephalomyelitis. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain. Bode and his colleagues obtained the Borna virus from three people who had been diagnosed with mood disorders. |
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