Borna disease

(redirected from Borna's disease virus)
Also found in: Dictionary, Wikipedia.

Borna disease

An infectious encephalopathy of warm-blooded animals, including ruminants (e.g., cattle, horses, sheep), foxes, dogs, cats, birds and primates, which occurs in Central Europe, caused by the Borna virus.
 
Clinical findings
Motor and behavioural symptoms—aggression, eating disorders, hyperactivity, postural disorders, ataxia, disrupted social and sexual activity.
 
Epidemiology
Uncertain, probably via saliva or nasal secretions.

Mortality
Up to 100% in horses, 50% in sheep.

Borna disease

a geographically restricted virus disease of horses and occasionally sheep, characterized by a uniformly fatal encephalomyelitis. Clinically it is characterized by pharyngeal paralysis, muscle tremor, lethargy and flaccid paralysis. The causative virus is a non-segmented, negative-stranded RNA virus with a nuclear site of replication and transcription of its genome. It is noncytolytic and highly neurotropic and is the prototype and only member thus far identified of the family Bornaviridae, in the order Mononegavirales. Serologic evidence indicates that the host range of Borna disease virus or an antigenically related virus is wide and the virus has been linked to psychiatric illnesses in humans. Called also Near Eastern equine encephalomyelitis.