Bordetella pertussis


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Bor·de·tel·la per·tus·'sis

the bacterial species that is the causative agent of whooping cough, a respiratory tract infection that in infants and young children may be life threatening; the severe cough, progressing to a paroxysmal form after 7-10 days, is associated with production of pertussis toxin, a protein consisting of 5 B. subunits that bind the molecule to respiratory epithelial cells, and an A subunit, an ADP-ribosyl-transferase that interferes with proteins associated with normal signal transduction; pathology is also associated with heavy secretion of mucus and hypoxia due to paroxysmal coughing and to blockage of air passages with mucus.

Bordetella pertussis

A small, aerobic, gram-negative bacillus, which classically causes whooping cough. B pertussis produces various toxins including a dermo-necrotising toxin, an adenyl cyclase, an endotoxin and pertussis toxin, as well as surface components such as fimbrial haemagglutinin.

Clinical findings
Runny nose, sneezing, mild cough, low-grade fever.
 
Diagnosis
Culture, serology.

Bordetella pertussis

Microbiology A small, aerobic, gram-negative bacillus, causative organism of whooping cough; B pertussis produces various toxins including a dermonecrotizing toxin, an adenyl cyclase, an endotoxin and pertussis toxin, as well as surface components such as fimbrial hemagglutinin Diagnosis Culture, serology, clinical Rx

Bor·de·tel·la per·tus·sis

(bōr-dĕ-tel'ă pĕr-tŭs'is)
A bacterial species that causes whooping cough; it produces cell-destroying toxins and causes thick mucus to collect in the airway. The type species of the Bordetella genus.

Bor·de·tel·la per·tus·sis

(bōr-dĕ-tel'ă pĕr-tŭs'is)
A bacterial species that causes whoo-ping cough.

Bordetella

a genus of gram-negative bacteria which cause respiratory disease in a number of species.

Bordetella avium
the cause of turkey coryza. Previously called Alcaligenes fecalis.
Bordetella bronchiseptica
a small, gram-negative, motile bacillus. A normal inhabitant of the respiratory tract in humans, dogs and pigs, but also causes pneumonia, stillbirths, abortions, canine infectious tracheobronchitis (see kennel cough) and atrophic rhinitis in pigs.
Bordetella parapertussis
implicated in pneumonia in sheep, in association with Mannheimia haemolytica.
Bordetella pertussis
the cause of whooping cough in humans. Used as an adjuvant for immunostimulation.
References in periodicals archive ?
Media first contained blood, serum or other biological materials until it was realized that unsaturated fatty acids, which are present agar, peptones, cotton stoppers and on glassware are produced endogenously during growth are toxic to Bordetella Pertussis.
The PCR test involves amplifying the Bordetella pertussis DNA and detecting a specific target sequence (IS481) using a probe.
Comparison of PCR, culture, and direct fluorescent-antibody testing for detection of Bordetella pertussis.
A search for Bordetella pertussis infection in university students.
Pertussis pseudo-outbreak linked to specimens contaminated by Bordetella pertussis DNA from clinic surfaces.
Some researchers have been concerned that changes in the genetics of Bordetella pertussis, the most common pertussis-causing microbe, could underlie the disease's resurgence.
Bordetella pertussis is the cause of whooping cough in humans while Bordetella bronchiseptica is associated with kennel cough in dogs.
The older formula, known as a whole-cell vaccine, contains killed Bordetella pertussis, the bacteria that causes whooping cough.
Dervied from inactivated whole-cell becterial suspension of Bordetella pertussis.
Global Markets Direct's, 'Bordetella Pertussis Infections - Pipeline Review, H2 2012', provides an overview of the Bordetella Pertussis Infections therapeutic pipeline.