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bone resorption

   Also found in: Dictionary/thesaurus, Wikipedia 0.56 sec.
bone resorption.
resorption (rēzôrp´shn),
n 1. loss of substance (bone) by physiologic or pathologic means; the reduction of the volume and size of the residual alveolar portion of the mandible or maxillae.
n 2. the cementoclastic and dentinoclastic action that often takes place on the root of a replanted tooth.
resorption, apical root,
n dissolution of the apex of a tooth, resulting in a shortened, blunted root.
resorption, bone,
n 1. destruction or solution of the elements of bone.
n 2. loss of bone resulting from the activity of multinucleated giant cells, the osteoclasts, which are noted in irregular concavities on the periphery of the bone (Howship's lacunae).
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Apical root resorption.
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Severe bone resorption in the mandible.
resorption, cemental,
n destruction of cementum by cementoclastic action. Noted as the presence of irregular concavities in the cemental surfaces.
resorption, frontal,
n osteoclastic resorption of alveolar bone (lamina dura) by multinucleated cells on the osseous margin adjacent to the periodontal ligament.
resorption, horizontal,
n a pattern of bone resorption in marginal periodontitis in which the marginal crest of the alveolar bone between adjacent teeth remains level; in these instances the bases of the periodontal pockets are supracrestal; a pattern of bone loss in which the crestal margins of the alveolar bone are resorbed. A horizontal pattern, rather than vertical loss along the root, is the typical type of bone loss in periodontitis.
n resorption that is not attributable to any known disease or is without an apparent cause.
resorption, internal,
n (idiopathic internal resorption, pink tooth), a special form of idiopathic root resorption from within the pulp cavity; granulation tissue is present within the tooth, apparently with the resportion of the dentin occurring from the inside outward. The cause is unknown.
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Internal resorption.
resorption, lacunar,
n loss of bone by cellular activity; osteoclasts are large, multinucleated cells seen in irregular concavities in the margin of the bone (Howship's lacunae) and currently believed to be directly responsible for the active destruction of bone.
resorption, pressure, of bone,
n osteoclastic destruction of bone resulting from the application of sustained, excessive force. Remodeling of bone may occur to better adapt to these forces, or destruction may continue if the stresses are repeated and excessive.
resorption, rear,
n See resorption, undermining.
resorption, root,
n destruction of the cementum or dentin by cementoclastic or osteoclastic activity.
resorption, surface root,
n localized resorptive areas on the cemental surface of the tooth root.
resorption, undermining,
n indirect, as opposed to frontal, removal of alveolar bone where pressure applied to a tooth has resulted in loss of vitality of localized areas of the periodontal ligament.
resorption, vertical,
n a pattern of bone loss seen in occlusal traumatism, marginal periodontitis, periodontosis, and other conditions; a pattern of bone loss in which the alveolar bone adjacent to a tooth is destroyed without simultaneous crestal loss, so that a vertical rather than a horizontal pattern of loss is observed.


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Preclinical and Phase 1 studies have shown that Ostabolin-C stimulates significant bone formation with little to no stimulation of bone resorption.
There are also some data suggesting that the hormone leptin, which is involved in regulating body weight and appetite, increases bone resorption (the process of losing bone).
Although there are drugs that prevent bone resorption by osteoclasts, only one Food and Drug Administration-approved compound, parathyroid hormone, stimulates bone formation.
 
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