bone marrow biopsy

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Related to bone marrow biopsy: bone marrow transplant, Bone marrow cancer

bone marrow biopsy

a microscopic tissue examination used to help evaluate patients with hematologic diseases. The biopsy may be done to confirm a diagnosis of megaloblastic anemia, to diagnose leukemia or myeloma, to determine the cause of reduced red blood cells in the peripheral bloodstream, to document deficient iron stores, to document bone marrow infiltrative diseases such as neoplasm or fibrosis, to identify tumors, and to diagnose a variety of other conditions.

bone marrow biopsy

(1) The insertion of a large-bore needle with a removable stylet into the iliac crest or sternum, to aspirate a sample of bone and bone marrow.

Evaluation of the marrow for leukaemia, multiple myeloma, lymphoma, anaemia and pancytopaenia.

(2) Commonly, the term bone marrow biopsy also refers (incorrectly) to the bone marrow examination itself.

bone mar·row bi·op·sy

(bōn marō bīop-sē)
Process whereby bone marrow is aspirated with a needle or trocar for microscopic examination.

bone marrow biopsy

A sample of marrow usually taken from the crest of the pelvis at the back under local anaesthesia using a broad stout needle attached to a syringe. Marrow biopsies allow diagnoses of the various forms of ANAEMIA, of failure of red cell production (aplastic anaemia), of reduced white cell production (AGRANULOCYTOSIS) and of the various kinds of white cell cancer (LEUKAEMIA).

Bone marrow biopsy

A procedure in which cellular material is removed from the pelvis or breastbone and examined under a microscope to look for the presence of abnormal blood cells characteristic of specific forms of leukemia and lymphoma.
Mentioned in: MALT Lymphoma


removal and examination, usually microscopic, of tissue from the living body. Biopsies are usually done to determine whether a tumor is malignant or benign; however, a biopsy may be a useful diagnostic aid in other disease processes such as infections.

aspiration biopsy
biopsy in which tissue is obtained by application of suction through a needle attached to a syringe.
bite biopsy
instrumental removal of a fragment of tissue.
bone marrow biopsy
obtaining a sample of bone marrow, usually by needle aspiration, from a long bone, rib or sternum, for cytological examination.
Enlarge picture
Needle aspiration of bone marrow. By permission from Ettinger SJ, Feldman E, Textbook of Veterinary Internal Medicine, Saunders, 2004
brush biopsy
removal of cells and tissue fragments using a brush with stiff bristles (introduced through an endoscope). Effective in obtaining tissue samples from inaccessible places such as the renal pelvis.
closed biopsy
one carried out without access through an open incision such as a laparotomy. An example is a percutaneous, fine needle aspirate.
cone biopsy
biopsy in which an inverted cone of tissue is excised, as from the uterine cervix.
cytological biopsy
obtaining specimens of cells by various methods including irrigation of a hollow tube.
biopsy dart
an alternative to immobilization of large and wild animals; a dart which cuts a skin bipsy, then falls out. Limited to use for superficial lesions.
endoscopic biopsy
removal of tissue by appropriate instruments through an endoscope.
excisional biopsy
biopsy of tissue removed from the body by surgical cutting.
exploratory biopsy
a combination of exploratory surgery to determine size and location of a lesion and the taking of a biopsy.
fine needle biopsy
see needle biopsy (below).
hepatic biopsy
may be by transperitoneal incision, more commonly by percutaneous needle or trocar and cannula technique.
incisional biopsy
biopsy of a selected portion of a lesion.
needle biopsy
biopsy in which tissue is obtained by puncture of a tumor, the tissue within the lumen of the needle being detached by rotation, and the needle withdrawn.
punch biopsy
see punch biopsy.
Robson-Heggers biopsy
a procedure for the collection of a piece of tissue from an infected wound in order to determine the extent and the nature of the infection.
sternal biopsy
biopsy of bone marrow of the sternum removed by puncture or trephining (see also sternal puncture).
surface biopsy
sample of cells scraped from the surface of a lesion or obtained by impression smears.
surgical biopsy
one obtained during a surgical procedure.
synovial biopsy
by a needle biopsy technique or through an arthrotomy incision using special forceps for a bite biopsy.
total biopsy
obtained by removal of the entire lesion. May be for therapeutic as well as diagnostic purposes.
ultrasound-guided biopsy
use of ultrasonography to guide the passage of a needle or biopsy instrument into an internal organ or lesion.
References in periodicals archive ?
A bone marrow biopsy performed at that time showed normocellular bone marrow with a small amount of amyloid deposits and no increase in plasma cells.
The main disadvantage of our study was that most patients had already started TB treatment when bone marrow biopsy was performed.
Thus, to our knowledge, this is the first reported case of atypical presentation of spontaneous cholesterol crystal embolization to bone marrow diagnosed premortem via bone marrow biopsy.
A bone marrow biopsy was performed; the aspirate was unsuccessful ("dry tap") but the biopsy material showed a fibrotic bone marrow with atypical megakaryocytes and megakaryoblasts (Figure 1, a).
Obtaining an adequate length of bone marrow biopsy is very important.
He was transferred to Newcastle's Royal Victoria Infirmary for a bone marrow biopsy which showed Anthony did not have cancer, but severe Aplastic Anaemia.
A bone marrow biopsy can provide a morphological diagnosis within a few days.
The cells were grown on the scaffold inside the bioreactor for approximately two days and the scaffold was rotated while its surface was soaked with stem cells obtained from a bone marrow biopsy from the patient's hip.
A bone marrow biopsy was not performed in view of the normal peripheral blood smear and imaging.
A bone marrow biopsy demonstrated 30% plasma cells with lambda restricted immunostaining, establishing the diagnosis of myeloma.
The patient underwent a complete blood count, bone marrow biopsy, urine and serum electrophoresis, and serum biochemistry (including measurements of calcium, blood urea nitrogen, creatinine, uric acid, and protein), and all results were found to be normal.