bombesin

(redirected from Bombesin receptor)
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bombesin

 [bom´bĕ-sin]
a tetradecapeptide neurotransmitter and hormone found in the brain and intestine; it is also found increased in cultures of small cell carcinoma of the lung.

bom·be·sin

(bomb'ĕ-sin),
Pharmacologically active tetradecapeptide found in skins of European amphibians of the family Discoglossidae, principally Bombina bombina and B. variegata variegata. A potent stimulant of gastric and pancreatic secretions; a bombesinlike immunoreactive peptide is found in both brain and gut. Other actions include hypertensive, antidiuretic, and hyperglycemic activity. Has a strong effect on core temperature lowering in rats. High levels of intracellular bombesin have also been found in human small-cell lung carcinoma.

bombesin

/bom·be·sin/ (bom´bĕ-sin) a tetradecapeptide neurotransmitter and hormone found in the brain and gut.

bombesin

[bom′bə·sin]
a neurohormone and pressor substance found in small amounts in brain and intestinal tissue under normal conditions and in increased amounts in certain pulmonary and thyroid tumors. It is a potent mitogen and its effects on gastrin and other hormones are attributed to increased cell numbers.

bombesin

A 14-residue neuropeptide hormone produced in the gastric antrum that stimulates gastrointestinal (GI) smooth muscle contraction and the release of gastric acid and GI hormones. Bombesin also acts on vasculature, gallbladder, pancreas, lung and urinary tract; in the cerebral cisterna it evokes hypothermia, analgesia, hyperglucagonaemia, hyperglycaemia, and stimulates proliferation of bronchial epithelial cells, pancreas, small cell carcinoma and thyroid tumours. Bombesin staining occurs in two-thirds of carcinoids and neuroendocrine tumours, including small cell carcinoma of the lung

bombesin

a tetradecapeptide found in the brain and gut.
References in periodicals archive ?
In vitro experiments have determined that a specific paclitaxel-bombesin peptide ligand (NBT-300) conjugate is able to deliver cytotoxic concentrations of taxanes via the bombesin receptor into several specific cancer cell lines, including breast, small cell lung, non-small cell lung, head and neck squamous cell, pancreatic, prostate, and neuroblastoma.
Levels of cytotoxicity varied with the level of bombesin receptor expression in each tumor line and the paclitaxel concentration.