BMP4


Also found in: Dictionary, Acronyms.
Related to BMP4: BMP3

BMP4

A gene on chromosome 14q22-q23 that encodes bone morphogenetic protein-4, which plays a key role in formation of teeth, limbs and bone from mesoderm, as well as fracture repair.
References in periodicals archive ?
Armfield and colleagues zeroed in on two proteins, BMP4 (Bone Morphogenetic Protein 4) and FGF8 (Fibroblast Growth Factor 8).
Moreover, we found that in hypertensive rats the protein levels of BMP4 are increased, and then oxidative stress and p38 MAPK are activated, resulting in upregulation of COX-2, where the pathway contributes to augmentation of EDCs.
Osr2 restricts Bmp4 expression to the tooth mesenchyme under the dental lamina, and in Osr2's absence, Bmp4 gene expression expands into the jaw mesenchyme outside of the tooth row.
Al parecer los germenes mas afectados son los premolares y molares porque la mutacion de genes MSX-1 afecta la cascada de BMP4 (26); ademas son los ultimos dientes en desarrollarse y por lo tanto son mas susceptibles a alteraciones (27).
See Bellish, supra note 9, at 19 (showing how implementing BMP4 recommendations have led to increased costs).
BMP4, supra note 38, at 3 ("The presence of Naval/Military forces in the Gulf of Aden .
Although BMP4 exhibits a wide variety of biological activities, its role in the liver still remains to be investigated.
But because the BMP4 and noggin molecules were directly in contact with the cells, much less growth factor was needed to spur the differentiation--approximately 12 times less than what would be required by conventional solution-based techniques.
En el crecimiento y elevacion de los procesos palatinos se ha involucrado principalmente a los genes Msx1, Tbx22, Bmp4, Bmp2, Lhx8(Figura 2B), y en el proceso de fusion se ha establecido un papel importante para el gen Tgfb3, Irf6y Pvrl1 entre otros (Figura 2C).
In molar patterning, Lhx6/7 maintain expression of Msx1 , and Msx1 stimulates Bmp4 [Zhang et al.
En el 2009 se publico la segunda version (BMP2), en 2010 BMP3, y en 2011 BMP4.
54) suggested that mutations in NKX2-5, GATA4, CRELD1 and BMP4 are infrequently found in patients with congenital cardiac septal defects.