BMP7

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BMP7

A gene on chromosome 20q13 that encodes bone morphogenetic protein-7, which plays a key role in cartilage formation, osteoblast differentiation, renal development and repair, and induces the production of SMAD1.
References in periodicals archive ?
Although the virus can't replicate, it infects the cells and induces some of them to mass-produce BMP-7 and others to take on the role of bone-building cells.
Currently, two of these proteins BMP-2 and BMP-7, are approved for clinical use in non-union, tibial fractures and spinal fusion procedures.
Compared to 1st generation DBM products, the AccellRx process on which Connexus is based yields a higher level of TGF- beta1 and nhBMPs, including BMP-2, BMP-4 and BMP-7, which act synergistically to stimulate new bone formation.
SVA uses the known 3D structure of the clinically validated BMP-7 protein and its corresponding cell surface receptors, along with the known activities of the other BMPs, to generate a rich set of active compounds.
We are thrilled to partner with Ember, a fiery company seeking to unleash the powerful biology of BMP-7," said Jonathan Ross Goodman, President and CEO of Knight.
NASDAQ: CRIS), a drug development company focused on seeking to develop proprietary targeted medicines primarily for cancer treatment, today announced that it has entered into an agreement to sell and assign its remaining BMP-7 technologies to Stryker Corporation.
This transaction further enhances the clinical utility and efficacy of BMP-7 in diverse applications and gives us access to novel delivery technologies for BMP-7," said Joseph Hernandez, Chairman of Mariel Therapeutics.
BMP-7 Technology to be Returned to Curis for Future License
Giltaij was responsible for the market introduction of OP-1R / BMP-7 in the European market for Stryker Biotech.
Under the revised agreement, Curis will screen for small molecule agonists that mimic the bioactivity of BMP-7 and activate the bone morphogenetic ("BMP") pathway.
The transaction covers all of Curis' proprietary BMP compounds including BMP-7, which has been studied in animal models as a treatment for systemic complications (renal osteodystrophy and vascular calcification) associated with chronic kidney diseases (CKD).