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Ewing sarcoma/peripheral primitive neuroectodermal tumour (EWS/PNET) is a malignant small round blue cell tumour.
These tumours are categorised as small round blue cell tumours.
1 EWS has a wide spectrum of differential diagnosis, and is morphologically indistinguishable from other round blue cell tumours.
Histopathological examination of specimens obtained during tumour resection revealed poorly differentiated malignant neoplasm with papillary features and small, round, blue cell tumour morphology.
Non-random chromosomal translocations of the ews gene on chromosomes 22q12 and 11q24 reveals clear evidence of ES/PNET and excludes other small, round, blue cell tumour pathology.
Microscopy revealed a highly necrotic and malignant small blue cell tumour.
Pathological and radiological differential diagnosis Small round blue cell tumour Radiological Non-Hodgkin's lymphoma Rhabdomyosarcoma Rhabdomyosarcoma Myosarcoma Small cell lung cancer Malignant fibrous Merkel cell cancer histiocytoma (MFH) Haemangiopericytoma Dedifferentiated liposarcoma Neuroblastoma Ewing's sarcoma Ewing's sarcoma Primitive neuro-ectodermal tumour (PNET)
On histological examination post-graduate residents diagnosed the tumour as a round blue cell tumour consistent with the diagnosis of Wilms' Tumour.
Conclusion: The ONB has great variability of histological and clinical presentation, and immunohistochemical markers are useful to differentiate from more common small round blue cell tumours of nasal cavity.
Poorly differentiated synovial sarcoma is composed of uniform densely packed, small ovoid blue cells that resemble other small round blue cell tumours.
Other important uses of immunohistochemistry include determination of unknown primary tumours6 diagnosis of central nervous system tumours, diagnosis of Paediatric small round blue cell tumours, carcinomas, Melanoma and sarcomas.
Small round blue cell tumours and solid paediatric malignancies require Immunohistochemistry for the diagnosis, evaluation of recurrent or metastatic disease and in some cases prognostic classification.