Blue Cell Tumour

(redirected from Blue Cell Tumor)
A usually malignant tumour, the cells of which are arranged in nests, sheets, and masses, and composed of relatively monotonous, round-to-oval, 8–15-µm in diameter cells with poorly defined cytoplasmic borders and strongly basophilic—blue—by H&E staining nuclei; embryologic origin often requires ancillary information provided by histologic pattern, immunohistochemistry, and rarely electron microscopy
DiffDx
Children Neuroblastoma, Ewing sarcoma, NHL, embryonal rhabdomyosarcoma
Adults Neuroendocrine tumour, mesenchymal chondrosarcoma, hemangiopericytoma, large cell lymphomas, Merkel cell tumour, small cell osteosarcoma, small/oat cell carcinoma, alveolar rhabdomyosarcoma
References in periodicals archive ?
1) Merkel cell carcinoma is seen as a small, blue cell tumor on histology and is distinguished from small-cell lung cancer and the small-cell variant of melanoma by immunohistochemistry.
This tumor arises in the retina and is a small, round blue cell tumor that exhibits apoptosis, with rosette and fleurette formation.
A diagnosis of "malignant small blue cell tumor with necrosis" was made, and a larger biopsy for chromosome analysis was performed 2 weeks later.
Medulloblastomas with favorable versus unfavorable histology: how many small blue cell tumor types are there in the brain?
An anterior-chamber fine-needle aspiration biopsy showed a small, round blue cell tumor, consistent with retinoblastoma (Figure 2, A and B).
Microscopic examination revealed a blue cell tumor, which lacked significant mitotic activity (<1 mitosis per 10 high-power fields).
Several unusual parameters contributed to the difficulty in making a diagnosis in this infant: young age, multiple masses without organomegaly or circulating blasts, and biopsy findings reminiscent of a small, round, blue cell tumor.
The presence and structure of tumor rosettes in small round blue cell tumors have much relevance in guiding one to a diagnosis, as outlined in Table 3, with examples illustrated in Figure 4, A and B.
A number of primitive, small round blue cell tumors are found in the CNS.
Medulloblastoma is a malignant embryonal tumor of the cerebellum, accounting for 14% of all pediatric central nervous system tumors, (3) and it is one of the so-called malignant small blue cell tumors bearing histological similarity to SCC.
Secondly, FNAB allowed for categorization of this lesion as a benign spindle cell tumor Uncommonly, small blue cell tumors, such as lymphoblastic lymphomas or peripheral neuroectodermal tumors, may present as cutaneous lesions during childhood,[8] and FNAB provides a rapid method to exclude this possibility.
Metastatic tumor is an important diagnostic consideration, especially in very young children, in whom clustering of megakaryoblasts may resemble neuroblastoma or other small blue cell tumors.