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blood substitute |
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blood substitute, a substance used for a replacement or volume expansion for circulating blood. Plasma, human serum albumin, packed red cells, platelets, leukocytes, and concentrates of clotting factors are often administered in place of whole blood transfusions in the treatment of various disorders. Substances that are sometimes used to expand blood volume include dextran, hetastarch, albumin solutions, or plasma protein fraction. Perfluorocarbon emulsions, although potentially toxic, have been tested as blood substitutes; they are able to carry oxygen to tissues, have a long shelf life without refrigeration, and do not induce antigen-antibody reactions. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Northfield is a medical research company that has produced PolyHeme, a blood substitute that's in its third and final stage of FDA testing. In the 1960s, researchers tried to circumvent complications from cell-surface antigens by making a blood substitute using free hemoglobin extracted from cells. SYBD currently is developing three products: Oxycyte(TM), a perfluorocarbon-based blood substitute and therapeutic oxygen carrier; Fluorovent(TM), a perfluorocarbon liquid ventilation product; and an implantable glucose biosensor for continuous monitoring of blood glucose levels in diabetics. |
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