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Blast crisis

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Blast crisis
Stage of chronic myelogenous leukemia where large quantities of immature cells are produced by the marrow and is not responsive to treatment.
Mentioned in: Bone Marrow Transplantation
blast crisis Blast phase, blast transformation Oncology The abrupt conversion of a chronic, relatively indolent leukemia usually CML into an acute decompensated, accelerated phase, with a marked–30+% of WBCs—↑ proportion of blasts and number of lymphocytes or myelocytes in circulation and BM Clinical Lymphadenopathy, hepatosplenomegaly, spleen and bone pain, fever, thrombosis Lab Leukocytosis, thrombocytosis or thrombocytopenia, anemia Management Response to BCs is usually short-lived; myeloblast transformations are commonly treated with hydroxyurea;1⁄4 respond to prednisone with vincristine. Cf Blast transformation, Relapse.


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In view of Philadelphia chromosome positivity and the patient's age, it might be suspected that the patient had CML presenting in blast crisis.
Granular acute lymphoblastic leukemia in adults: report of a case and ... by Mazzella, Fermina M. / Southern Medical Journal
CML progresses through three distinct phases: the chronic phase (typically lasting from four to five years), the accelerated phase (typically lasting from six to 18 months) and blast crisis (typically lasting from three to six months).
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Researchers also studied the effect of Glivec on patients in blast crisis - 38 had
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