In the present study there wasn't a correlation between FLT3 gene mutations, and age, gender, the WBCcount, blast cell
rate, or FAB classification.
The number of blast cells
in the peripheral blood should be subtracted from the number of blasts in the CSF and the blasts in the CSF reported as two percent.
Results are expressed as percentages of labeled blast cells
To monitor the further development of the patient's disorder, a complete automated blood cell count and a differential cell count were performed almost every day until disappearance of blast cells
and other atypical cells.
The building includes approximately 17,000 square feet of rack support freezer, four blast cells
, 37,000 square feet of climate controlled manufacturing and warehouse areas, and approximately 10,000 square feet of racked ambient storage warehouse.
9]/L, and no evidence of leukemia in other sites); nonresponder (NR; cellular marrow with >5% blast cells
or evidence of leukemia in other sites, after at least two courses of chemotherapy); and early relapse (ER; relapse within 6 months from remission) (21).
No blast cells
were identified in the peripheral smear.
The new freezers will maintain temperatures -10 [degrees] F and the blast cells
will operate at -30 [degrees] F.
The red cell count should be low, since the presence of many blast cells
in the bone marrow tends to crowd them out.
The most dramatic improvement in overall survival was seen in 19 patients who also showed either bone marrow complete response (CR) or initial >50% decrease in blast cells
Cases with <20% blast cells
may still be diagnosed as acute leukemia if they present with certain recurrent cytogenetic abnormalities, as in AML M4 with inv (16) or t (16;16) (p13;q22) and AML M2 with t (8), (21)
The clinical study also measured intracellular uptake of LOR-2040 in the bone marrow leukemic cells, and identified significant accumulation of the drug in the bone marrow blast cells
and suggested preferential uptake of the drug by CD34+ cells, an important malignant bone marrow cell population.