Bivalirudin in Combination with Eptifibatide

Bivalirudin in Combination with Eptifibatide

A trial which compared the haematologic and clinical effects the direct thrombin antagonist bivalirudin given in combination with the glycoprotein IIb/IIIa antagonist eptifibatide.

Primary endpoints
MI or bleeding.
 
Conclusion
Heparin can be substituted with bivalirudin in patients treated with eptifibatide needing percutaneous coronary intervention; more data are needed to assess the combination’s safety and efficacy.