The Birbeck granule
, a trilaminar rod-like organelle with a terminal expansion resembling a tennis racquet, is distinctive.
The typical non-Langerhans' foamy histiocytes that lacked Birbeck granules
, located in a polymorphic granuloma with xanthogranulomatosis was shown.
These cells express S100 protein, CD1a, and langerin (CD207) and contain intracytoplasmic Birbeck granules
1,2) The major diagnostic features of LCH are expression of CD1a and S100 as well as ultrastructural Birbeck granules
Langerhans cells are dendritic antigen presenting cells with distinctive convoluted nuclear contour, presence of Birbeck granules
on electron microscopy and positive staining with S-100 and CD1a.
The presence of birbeck granules
in the cytoplasm is characterictic.
Langerhans cells have cytoplasmic inclusion bodies known as Birbeck granules
; a definitive diagnosis requires electron microscopy of Birbeck granules
or CD 1 antigenic determinants by immunohistochemistry.
The immunoprofile is (CD1a+, S100+), and some cells should have the characteristic LC features of grooved nuclei and/or Birbeck granules
S-100, CD 68 and CD-1a stains were positive and Birbeck granules
were seen on electron microscopy (EM), confirming the diagnosis.
Some clinicians believe that the cells are precursors to Langerhans' cells, obtaining Birbeck granules
as they climb into the epidermis.
Electron micrograph of follicular dendritic cell sarcoma shows well-developed, long interdigitating cytoplasmic processes and desmosome-like junctions; no Birbeck granules
are seen (original magnification X20 000).
are intracellular in location having a tennis racket appearance and identified by electron microscopy.