Birbeck granule

Lan·ger·hans gran·ule

a small, tennis racket-shaped membrane-bound granule with characteristic cross-striated internal ultrastructure; first reported in Langerhans cells of the epidermis.
See also: eosinophilic granuloma.
Synonym(s): Birbeck granule
A subcellular particle with a pentalaminar ‘handle’ and bulbous terminal dilatation of uncertain significance that is seen by electron microscopy in the antigen-presenting Langerhans’ cell and in histiocytes


Michael S., English cancer researcher.
Birbeck granule - Synonym(s): Langerhans granule

Birbeck granule

a 'tennis-racquet' organelle characteristic of human Langerhans cells; in animals occur only in Langerhans cells in cattle.
References in periodicals archive ?
The Birbeck granule, a trilaminar rod-like organelle with a terminal expansion resembling a tennis racquet, is distinctive.
Electron microscopy was significant for the presence of numerous Birbeck granules (Figure 3).
Langerhans cells have cytoplasmic inclusion bodies known as Birbeck granules; a definitive diagnosis requires electron microscopy of Birbeck granules or CD 1 antigenic determinants by immunohistochemistry.
The immunoprofile is (CD1a+, S100+), and some cells should have the characteristic LC features of grooved nuclei and/or Birbeck granules.
Langerhans cell histiocytosis is a neoplastic proliferation of Langerhans cells, demonstrating immunohistochemical expression of CD1A and S100 as well as ultrastructural evidence of Birbeck granules.
S-100, CD 68 and CD-1a stains were positive and Birbeck granules were seen on electron microscopy (EM), confirming the diagnosis.
The hallmark of Langerhans cells is the ultrastructural presence of cytoplasmic Birbeck granules, which are rod- or tennis-racket-shaped structures (figure, D).
6) Birbeck granules are the characteristic ultrastructural findings in LCs.
15) The sighting of Birbeck granules (also known as HX bodies) in the cytoplasm of Langerhans' cell histiocytes on electron microscopy is pathognomonic.