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biperiden

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biperiden /bi·per·i·den/ (-per´ĭ-den) an antidyskinetic used as the hydrochloride and lactate salts in the treatment of parkinsonism and drug-induced extrapyramidal reactions.
biperiden [bi-per´ĭ-den]
a synthetic anticholinergic used as an antidyskinetic to reduce the tremors of parkinsonism and for the treatment of drug-induced extrapyramidal reactions; administered orally as the hydrochloride salt and intramuscularly or intravenously as the lactate salt. Side effects are minor and include dryness of the mouth, blurring of vision, drowsiness, and nausea. Biperiden is contraindicated in patients with epilepsy and should be given with great care to patients with glaucoma.


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This has been shown through many case reports, with at least partial response to anticholinergics (amitripryline, trihexyphenidyl, benztropine, biperiden, pirenzepine, ipratropium, scopolamine, hyoscine, atropine, and glycopyrrolate) and [alpha]-blockers (clonidine, lofexidine, guanfacine, and terazosin).
A host of medications--for example, alcohol, amphetamines, anticholinergics, antidepressants other than bupropion, biperiden, cocaine, sedative-hypnotics, and selegiline--might precipitate REM sleep behavior disorder, as can withdrawal from alcohol, hypnotic agents, and REM suppressants.
Discontinuing biperiden 2-6 mg/day that had been given for 1 year or longer in elderly patients with schizophrenia improved DM.
 
 
 
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