bioassay

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bioassay

 [bi″o-as´a]
determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard.

bi·o·as·say

(bī'ō-as'ā),
Determination of the potency or concentration of a compound by its effect on animals, isolated tissues, or microorganisms, as compared with an analysis of its chemical or physical properties.

bioassay

/bio·as·say/ (bi´o-as″a) determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard.

bioassay

(bī′ō-ăs′ā′, -ă-sā′)
n.
1. Determination of the strength or biological activity of a substance, such as a drug, by comparing its effects with those of a standard preparation on a test organism.
2. A test used to determine such strength or activity.
tr.v. bioas·sayed, bioas·saying, bioas·says
To cause to undergo a bioassay.

bioassay

[bī′ō·as′ā, -əsā′]
Etymology: Gk, bios + Fr, assayer, to try
the laboratory determination of the concentration of a drug or other substance in a specimen by comparing its effect on an organism, an animal, or an isolated tissue with that of a standard preparation. Also called biological assay.

bioassay

Lab medicine
Any quantification procedure to detect:
(1) The activity or potency—functional or effective—amount of a substance—e.g., antibiotic, chemical, drug, hormone, metabolit, vitamin, etc.—in a biological fluid;
(2) Toxicity of a substance (e.g., a pollutant) or organism (e.g., a pathogen) of interest in an in vivo system, i.e., in a cell or animal; in bioassays, the effect is tested on living cells or organisms.
 
Molecular biology
An assay that uses a living system, such as an intact cell, to measure an effect or a molecule of interest.
 
Radiation physics
A determination of the quantity of radioactive material in the human body, either by direct measurement—in vivo counting—or by analysis of excreta.

bi·o·as·say

(bī'ō-as'ā)
Determination of the potency or concentration of a compound by its effect on animals, isolated tissues, or microorganisms, as contrasted with analysis of its chemical or physical properties.
Synonym(s): biologic assay, biotest.

bioassay

A method of measuring the potency of a drug or other biochemical agent by comparing its effects on animals with those of known preparations of standard strength.

bioassay

determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard.
References in periodicals archive ?
Most biological assays are performed on immobilized fluorophores.
Early estimates of CCK-like activity in blood were based on biological assays such as pancreatic secretion or gallbladder contraction.
Compared to currently available antibody technology on the market, such as mouse hybridomas, Epitomics' technology can generate antibodies with superior binding affinity and bioactivity in a wide variety of biological assays.
Lack of biological assays to measure many of these contaminants in tissue specimens, the high cost of using these assays in large epidemiologic studies when they were available, and challenges related to the interpretation of the results when exposures were measured after the adverse reproductive event occurred limit the conclusions that can be drawn from these investigations.
Cambridge, MA) is introducing an open platform allowing industrial, academic and clinical scientists to develop and use multiplexed biological assays on standard laboratory instrumentation.
The new name formalizes a shift in corporate strategy, reflecting the company's dedication to the continued development of high-quality filter plates, assay/storage plates, and reagent reservoirs for biological assays and drug discovery.
The nematode s versatile genetic tools, its biochemical tractability, and the powerful molecular replacement technologies available, this makes for a uniquely attractive experimental system to address the mechanisms employed by dynein regulators through a combination of biochemical, proteomic, and cell biological assays.
The patent comprises broad claims relative to electromagnetic elements on biochips for various biological assays.
The database currently tags 158,000 individuals working with Biological Assays.
The journal will specifically emphasize both the fundamentals of microscale transports of heat, mass, momentum and species as well as the application of these to specific areas like electronic cooling, micromachines for miniaturized mechanical devices including MEMS (and NEMS), synthesis and characterization of nanoparticles and nanostructured surfaces like super hydrophobic surfaces and their applications in industrial and health care systems, micro and nano scale measurements, microfluidic devices for surgery and medicine, bio-MEMS for novel biological assays and similar other applications.
Biosimilars are approved by the FDA based on the totality of evidence and on extensive comparisons to the reference product, including detailed analytical and biological assays, followed by nonclinical and pharmacokinetic/pharmacodynamic studies and then confirmation in a clinical setting.
The new instrument is currently being validated for performance using well characterized biological assays.

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