bioassay

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bioassay

 [bi″o-as´a]
determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard.

bi·o·as·say

(bī'ō-as'ā),
Determination of the potency or concentration of a compound by its effect on animals, isolated tissues, or microorganisms, as compared with an analysis of its chemical or physical properties.

bioassay

/bio·as·say/ (bi´o-as″a) determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard.

bioassay

(bī′ō-ăs′ā′, -ă-sā′)
n.
1. Determination of the strength or biological activity of a substance, such as a drug, by comparing its effects with those of a standard preparation on a test organism.
2. A test used to determine such strength or activity.
tr.v. bioas·sayed, bioas·saying, bioas·says
To cause to undergo a bioassay.

bioassay

[bī′ō·as′ā, -əsā′]
Etymology: Gk, bios + Fr, assayer, to try
the laboratory determination of the concentration of a drug or other substance in a specimen by comparing its effect on an organism, an animal, or an isolated tissue with that of a standard preparation. Also called biological assay.

bioassay

Lab medicine
Any quantification procedure to detect:
(1) The activity or potency—functional or effective—amount of a substance—e.g., antibiotic, chemical, drug, hormone, metabolit, vitamin, etc.—in a biological fluid;
(2) Toxicity of a substance (e.g., a pollutant) or organism (e.g., a pathogen) of interest in an in vivo system, i.e., in a cell or animal; in bioassays, the effect is tested on living cells or organisms.
 
Molecular biology
An assay that uses a living system, such as an intact cell, to measure an effect or a molecule of interest.
 
Radiation physics
A determination of the quantity of radioactive material in the human body, either by direct measurement—in vivo counting—or by analysis of excreta.

bi·o·as·say

(bī'ō-as'ā)
Determination of the potency or concentration of a compound by its effect on animals, isolated tissues, or microorganisms, as contrasted with analysis of its chemical or physical properties.
Synonym(s): biologic assay, biotest.

bioassay

A method of measuring the potency of a drug or other biochemical agent by comparing its effects on animals with those of known preparations of standard strength.

bioassay

determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard.
References in periodicals archive ?
A general procedure in fluorescence-based assays is to conjugate a fluorophore to some probe and use the fluorescence as an indicator of the presence of the probe molecules in the biological assay [7].
Early estimates of CCK-like activity in blood were based on biological assays such as pancreatic secretion or gallbladder contraction.
Microfluidic Systems was founded in 2001 and is focused on the development of microfluidic systems for automated preparation of biological assays.
The ISB researchers have applied microfluidics--the study of how fluids behave at the nano level--to successfully conduct biological assays on single cells.
These modified AFM tips allow rapid and reliable screening of samples for targeted molecular interactions of material, chemical, or biological assays.
Bruce Evans and Martin Reaney carried out the biological assays in Larry Gusta's laboratory at the University of Saskatchewan.
Meso Scale Discovery, a division of Meso Scale Diagnostics, LLC (MSD[R]) develops and markets solutions for multiplex biological assays, including assays for biomarkers, cytokines and phosphoproteins.
This process has been very rapid for prototyping novel molecules, from idea to hit compound validation in biological assays in less than 6 months.
This partnership will focus on screening ChromaDex's natural product libraries against certain biological assays and tumor models, with the intent of identifying high value, potentially patentable natural products for specific therapeutic indications.
Compared to currently available antibody technology on the market, such as mouse hybridomas, Epitomics' technology can generate antibodies with superior binding affinity and bioactivity in a wide variety of biological assays.
Lack of biological assays to measure many of these contaminants in tissue specimens, the high cost of using these assays in large epidemiologic studies when they were available, and challenges related to the interpretation of the results when exposures were measured after the adverse reproductive event occurred limit the conclusions that can be drawn from these investigations.
This will be accomplished through the use of TIM-2 (the company's in vitro model of the large intestine), in vivo studies, in vitro biological assays and pattern-recognition.

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