bioassay

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bioassay

 [bi″o-as´a]
determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard.

bi·o·as·say

(bī'ō-as'ā),
Determination of the potency or concentration of a compound by its effect on animals, isolated tissues, or microorganisms, as compared with an analysis of its chemical or physical properties.

bioassay

/bio·as·say/ (bi´o-as″a) determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard.

bioassay

(bī′ō-ăs′ā′, -ă-sā′)
n.
1. Determination of the strength or biological activity of a substance, such as a drug, by comparing its effects with those of a standard preparation on a test organism.
2. A test used to determine such strength or activity.
tr.v. bioas·sayed, bioas·saying, bioas·says
To cause to undergo a bioassay.

bioassay

[bī′ō·as′ā, -əsā′]
Etymology: Gk, bios + Fr, assayer, to try
the laboratory determination of the concentration of a drug or other substance in a specimen by comparing its effect on an organism, an animal, or an isolated tissue with that of a standard preparation. Also called biological assay.

bioassay

Lab medicine
Any quantification procedure to detect:
(1) The activity or potency—functional or effective—amount of a substance—e.g., antibiotic, chemical, drug, hormone, metabolit, vitamin, etc.—in a biological fluid;
(2) Toxicity of a substance (e.g., a pollutant) or organism (e.g., a pathogen) of interest in an in vivo system, i.e., in a cell or animal; in bioassays, the effect is tested on living cells or organisms.
 
Molecular biology
An assay that uses a living system, such as an intact cell, to measure an effect or a molecule of interest.
 
Radiation physics
A determination of the quantity of radioactive material in the human body, either by direct measurement—in vivo counting—or by analysis of excreta.

bi·o·as·say

(bī'ō-as'ā)
Determination of the potency or concentration of a compound by its effect on animals, isolated tissues, or microorganisms, as contrasted with analysis of its chemical or physical properties.
Synonym(s): biologic assay, biotest.

bioassay

A method of measuring the potency of a drug or other biochemical agent by comparing its effects on animals with those of known preparations of standard strength.

bioassay

determination of the active power of a drug sample by comparing its effects on a live animal or an isolated organ preparation with those of a reference standard.
References in periodicals archive ?
At the conclusion of the meeting, the insights gained at this event will give biologics researchers a better understanding of bioassays that reflect true MOA, are robust, sensitive and reproducible.
The expected mortality, E, from spinosad-SfMNPV mixture bioassays was considered an independent variable (Finney 1964) and determined according to Equation 1.
Based in Codolet, France, Cisbio Bioassays owns facilities in Bedford, MA, U.
At the conclusion of the bioassays, test specimens were removed from the jars and cleaned.
The last bioassay on each replication was run 8 days after the initial application of malathion, but survival levels on control plates on the last bioassay was not different from that of the first or second bioassays in each replication ([r.
Cisbio Bioassays is a global developer of products and technologies used in in vitro diagnostics and assay development for drug screening procedures.
Screening of the extract for biological activity started with the brine shrimp lethality bioassay, followed by the study of its antihypertensive activity on anaesthetized rats, which involved monitoring of the extract's effect on mean arterial blood pressure.
We developed and validated a yeast-based bioassay to measure androgen bioactivity in clinical samples, including human serum, for the detection of androgen-like and antiandrogenic compounds (9).
The objectives of this review are to discuss some of the key methodological obstacles in designing and selecting an appropriate screening bioassay and some of the most commonly used screening bioassays for assessing allelopathic potential in crop germplasm.
The company's LabMAPTM system is an open-architecture, multi-analyte technology platform that delivers fast, accurate and cost-effective bioassay results to markets as diverse as pharmaceutical drug discovery, clinical diagnostics and biomedical research.
Cancer assessments are based primarily on bioassays, but these bioassays are flawed because effects on animals do not equal effects on man and vice versa, and effects of large doses over short time spans are not the same as low doses over long time spans, he said.
New toxin types are usually indicated by inexplicable symptoms produced in mice injected with shellfish or plankton extracts for regulatory bioassays.