artificial liver

(redirected from Bioartificial Liver)
An extracorporeal supportive device for a person with acute liver failure. Bioartificial livers are not intended as permanent replacements, but as stop-gaps while one is awaiting liver transplantation. The current generation devices contain hepatocytes embedded in a gel. The patient’s plasma is removed and circulated through the device and returned, minus the metabolic wastes produced by the body which are normally removed by a healthy liver

artificial liver

Biotech A cartridge with cloned human liver cells, through which blood flows to facilitate removal of waste products. See Extracorporeal liver assist device, Liver dialysis.

artificial liver

A biomechanical device typically combining a system of filters to remove toxins from the blood with hepatic cells or tissue. It is designed to support patients with hepatic failure temporarily until a donor liver becomes available for transplantation.
See also: liver

artificial liver

An as yet unrealized entity that is, nevertheless, the subject of promising research and development. Current ambitions are to produce extracorporeal devices that will enable patients with liver failure to be kept alive until regeneration of transplantation is achieved. The principal difficulty arises from the large number of different metabolic functions performed by the liver. A promising approach is the use of cloned human liver cells grown around numerous fine semipermeable tubules through which the patient's blood is passed.
References in periodicals archive ?
Area: Ophthalmology Therapeutic applications: Retinal and macular degenerative diseases Bioadhesive for tissue regeneration Cultivated oral mucosal epithelial transplantation (COMET) Liver Therapeutic applications: Liver failure Example of Tissue Engineering Modalities: Extracorporeal artificial liver Extracorporeal bioartificial liver (BAL) Hepatocyte transplantation Transplantable liver constructs
It confirms that previously reported findings of improved transplant free survival (TFS) in Chinese subjects with acute-on-chronic liver failure (ACLF) treated with the ELAD(R) bioartificial liver support system are maintained for up to three years.
Summary: Bioartificial Liver Trial Now at Halfway Point .
Today's results demonstrate that, while inside our bioartificial liver device, HepaLife's PICM-19 cells are able to produce substantial amounts of urea and remove toxic ammonia, while remaining healthy, and replicating important liver-like functions," stated Frank Menzler, president and CEO of HepaLife.
The Arbios product candidate portfolio includes the SEPET Liver Assist Device, a novel blood purification therapy that provides enhanced "liver dialysis," and the HepatAssist Cell-Based Liver Support System, a bioartificial liver that combines blood detoxification with liver cell therapy to replace whole liver function in patients with the most severe forms of liver failure.
The trial is studying a bioartificial liver treatment in patients with chronic liver disease at Beijing Youan and 302 Military Hospitals in Beijing.
Molecular adsorbent recycling system (MARS): clinical results of a new membrane-based blood purification system for bioartificial liver support.
An extracorporeal bioartificial liver that uses pig hepatocytes appears to significantly improve survival of patients either with acute liver failure or after unsuccessful liver transplantation, according to the first randomized, multicenter trial of its kind.
Vivek Dixit, Development of a Bioartificial Liver Using Isolated Hepatocytes, Artif Organs, 18 (5), p 371-384 (1994).
A bioartificial liver using pig hepatocytes was successfully placed in a child waiting for a liver transplant.
focuses on the development of a cell-based bioartificial liver system, known as HepaMate[TM].
Arbios' products in development include SEPETTM, a novel blood purification therapy employing selective plasma filtration therapy, BAL 2004, a first-generation bioartificial liver (BAL) recently acquired from Circe Biomedical, Inc.