Area: Ophthalmology Therapeutic applications: Retinal and macular degenerative diseases Bioadhesive for tissue regeneration Cultivated oral mucosal epithelial transplantation (COMET) Liver Therapeutic applications: Liver failure Example of Tissue Engineering Modalities: Extracorporeal artificial liver Extracorporeal bioartificial liver
(BAL) Hepatocyte transplantation Transplantable liver constructs
It confirms that previously reported findings of improved transplant free survival (TFS) in Chinese subjects with acute-on-chronic liver failure (ACLF) treated with the ELAD(R) bioartificial liver
support system are maintained for up to three years.
Summary: Bioartificial Liver
Trial Now at Halfway Point .
Today's results demonstrate that, while inside our bioartificial liver
device, HepaLife's PICM-19 cells are able to produce substantial amounts of urea and remove toxic ammonia, while remaining healthy, and replicating important liver-like functions," stated Frank Menzler, president and CEO of HepaLife.
The Arbios product candidate portfolio includes the SEPET Liver Assist Device, a novel blood purification therapy that provides enhanced "liver dialysis," and the HepatAssist Cell-Based Liver Support System, a bioartificial liver
that combines blood detoxification with liver cell therapy to replace whole liver function in patients with the most severe forms of liver failure.
The trial is studying a bioartificial liver
treatment in patients with chronic liver disease at Beijing Youan and 302 Military Hospitals in Beijing.
Molecular adsorbent recycling system (MARS): clinical results of a new membrane-based blood purification system for bioartificial liver
An extracorporeal bioartificial liver
that uses pig hepatocytes appears to significantly improve survival of patients either with acute liver failure or after unsuccessful liver transplantation, according to the first randomized, multicenter trial of its kind.
Vivek Dixit, Development of a Bioartificial Liver
Using Isolated Hepatocytes, Artif Organs, 18 (5), p 371-384 (1994).
A bioartificial liver
using pig hepatocytes was successfully placed in a child waiting for a liver transplant.
focuses on the development of a cell-based bioartificial liver
system, known as HepaMate[TM].
Arbios' products in development include SEPETTM, a novel blood purification therapy employing selective plasma filtration therapy, BAL 2004, a first-generation bioartificial liver
(BAL) recently acquired from Circe Biomedical, Inc.