cholangiocarcinoma

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cholangiocarcinoma

 [ko-lan″je-o-kahr″sĭ-no´mah]
1. an adenocarcinoma arising from the epithelium of the intrahepatic bile ducts, composed of eosinophilic cuboidal or columnar epithelial cells, with abundant fibrous stroma; mucus may be secreted but not bile.

chol·an·gi·o·car·ci·no·ma

(kō-lan'jē-ō-kar'si-nō'mă),
An adenocarcinoma, primarily in intrahepatic bile ducts, composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant fibrous stroma; cirrhosis is usually absent.

cholangiocarcinoma

/cho·lan·gi·o·car·ci·no·ma/ (ko-lan″je-o-kahr″sĭ-no´mah)
1. an adenocarcinoma arising from the epithelium of the intrahepatic bile ducts and composed of epithelial cells in tubules or acini with fibrous stroma.

cholangiocarcinoma

[kōlan′jē·ōkär′sinō′mə]
a cancer of the biliary epithelium. Risk factors include ulcerative colitis and infestation of liver flukes. Diagnosis is based on histological evaluation, and the prognosis is poor.

cholangiocarcinoma

A rare (5/105/year) cancer of intrahepatic bile ducts, seen > age 60.
 
Aetiology
Anabolic steroids, liver flukes (Clonorchis sinensis), ulcerative colitis, cholecystitis, cholelithiasis, primary sclerosing cholangitis, malformations, cirrhosis.

Clinical findings
Obstruction, jaundice, abdominal pain, weight loss.

Location
Hilar, 50–60%; intrahepatic, 10%; extrahepatic 20–30%.

Prognosis
53% 1-year survival; 4% 5-year survival.

cholangiocarcinoma

Bile duct cancer, cancer of bile ducts A rare–5/100,000/yr cancer of intrahepatic bile ducts seen > age 60 Etiology Anabolic steroids, Thorotrast,.Clonorchis sinensis, possibly ulcerative cholitis, cholecystitis; not associated with alcohol abuse Clinical Jaundice—71%, abdominal pain-49%, weight loss—44% Prognosis 53% 1-yr survival, 9% 3-yr, 4% 5-yr. Cf Hepatocellular carcinoma.

chol·an·gi·o·car·ci·no·ma

(kō-lan'jē-ō-kahr-si-nō'mă)
An adenocarcinoma, primarily in intrahepatic bile ducts, composed of ducts lined by cuboidal or columnar cells that do not contain bile, with abundant fibrous stroma.

cholangiocarcinoma

Cancer of the bile ducts.

cholangiocarcinoma

see cholangiocellular carcinoma.
References in periodicals archive ?
Locoregional recurrence, as opposed to distant metastases, is usually the first site of disease recurrence and occurs in up to 59% of patients with perihilar bile duct carcinomas.
Complete surgical resection with microscopically negative surgical margins is an important predictor of outcome in multivariate analysis for both perihilar and distal bile duct carcinomas, with overall 5-year survival for perihilar tumor improved from 10% for all patients to 30% for those with negative resection margins.
The regional nodes for distal bile duct carcinomas are the same as those for carcinomas of the pancreatic head and include the following: lymph nodes along the common bile duct, hepatic artery, and celiac trunk; posterior and anterior pancreaticoduodenal nodes; and nodes along the superior mesenteric vein and the right lateral wall of the superior mesenteric artery.
Mucin core protein expression in extrahepatic bile duct carcinoma is associated with metastases to the liver and poor prognosis.
This pattern of strong expression of CK7 and negative expression of CK20 was most frequent in carcinomas of the ampulla or pancreas, but the majority of gallbladder and bile duct carcinomas also had this profile.