hydralazine

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hydralazine

 [hi-dral´ah-zēn]
an antihypertensive agent and vasodilator, administered orally, intramuscularly, or intravenously as the hydrochloride salt in treatment of peripheral vascular disease, essential and early malignant hypertension, thrombophlebitis, and other conditions in which dilation of blood vessels of the extremities is desired. Dosage is adjusted to the individual patient's response. blood pressure should be checked frequently, especially during parenteral administration. Side effects are rare with therapeutic doses, but the drug must be administered with caution to patients with coronary artery disease, advanced kidney damage, and existing or incipient stroke syndrome.

hydralazine

/hy·dral·a·zine/ (hi-dral´ah-zēn) a peripheral vasodilator used in the form of the hydrochloride salt as an antihypertensive.

hydralazine

(hī-drăl′ə-zēn′)
n.
An antihypertensive drug, C8H8N4.

hydralazine

Therapeutics A vasodilator which, with isosorbide dinitrate, is a 2nd line therapy in Pts with CHF for whom ACE inhibitors are contraindicated. See Congestive heart failure.

hydralazine

A drug that causes arteries to widen (vasodilatation) and can be used as an adjunct to the treatment of high blood pressure (HYPERTENSION) and moderate degrees of HEART FAILURE. It is seldom used alone. The drug is on the WHO official list. A brand name is Apresoline.

hydralazine

an antihypertensive and vasodilator drug that relaxes arteriolar smooth muscle by direct action. It is used as the hydrochloride in peripheral vascular disease, thrombophlebitis and congestive heart failure.
References in periodicals archive ?
Our two case studies reveal how customizing health seems to be an operation of inclusion (directly or indirectly by race) within biomedicine: BiDil is a customized drug that attends to black health; it targets racial minorities supposedly to extend life.
Heart disease is a disease of poverty that could most effectively be treated through structural change, but, instead, BiDil works to reify race as biology, which serves a number of political imperatives, including the maintenance of systemic racist practices in the U.
While other commentators have disagreed with the negative characterization of the BiDil trials, (14) there seems little doubt that different perspectives on the strength of the research exist in the academic literature.
BiDil is contraindicated in patients who are allergic to organic nitrates.
In an October article in Health Affairs' online edition, researchers Pamela Sankar and Jonathan Kahn lay out the disturbing process by which BiDil won its race-specific patent.
More drugs like BiDil may be coming, but "I don't think this is where we want to go," he said.
US FDA approves BiDil heart failure drug for African-American patients, Jun 23 2005 http://www.
The FDA reports the approval of BiDil was based in part on the results of the African-American Heart Failure Trial (A-HeFT).
Many physicians hail BiDil, which is produced by NitroMed in Lexington, Mass.
The trial was stopped prematurely in July 2004 after analysis showed death rates in those receiving BiDil were 43 percent lower than those receiving placebo.
These protestations crumble in the face of one simple fact: In large-scale clinical trials BiDil provided a selective benefit to black patients with heart failure; white patients who took the drug had the same results as those on placebo.
The substantial period-over-period decreases in total operating expenses are primarily the result of NitroMed's implementation of a restructuring plan in January 2008, which included substantial reductions in employee headcount and the discontinuation of promotional activities for BiDil.