Bicuculine | definition of Bicuculine by Medical dictionary
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An alkaloid naturally occurring in the d-form; found in Dicentra cucullaria and Adlumia fungosa (family Fumariaceae) and several Corydalis species; a powerful convulsant that acts by antagonizing γ-aminobutyric acid, an inhibitory neurotransmitter.
bicuculline A photosensitive alkaloid first derived from Dicentra cucullaria, which is also found in Adlumia fungosa and herbs of genus Corydalis and Fumariaceae. It is a competitive antagonist of the neurotransmitter gamma-aminobutyric acid at the GABAA receptor, and has been used in model systems for epilepsy.