Bicuculine | definition of Bicuculine by Medical dictionary
bicuculline (redirected from Bicuculine)
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An alkaloid naturally occurring in the d-form; found in Dicentra cucullaria and Adlumia fungosa (family Fumariaceae) and several Corydalis species; a powerful convulsant that acts by antagonizing γ-aminobutyric acid, an inhibitory neurotransmitter.
bicuculline A photosensitive alkaloid first derived from Dicentra cucullaria, which is also found in Adlumia fungosa and herbs of genus Corydalis and Fumariaceae. It is a competitive antagonist of the neurotransmitter gamma-aminobutyric acid at the GABAA receptor, and has been used in model systems for epilepsy.
References in periodicals archive
All recording slices were treated with phaclofen or bicuculine with asiatic acid various concentrations, while the other drug-untreated control was treated with phaclofen or bicuculine containing no asiatic acid.
The blocking effects are considerably greater in slices with concentration of 100 [micro]M with GABAA antagonist, bicuculine.
Dihydropyridine calcium channels blockers in experimental seizures by ischemia, bicuculine
, electrical cortical shocks, nitrous oxide and alcohol withdrawal syndrome is caused due, have anticonvulsant effects .