bicuculline

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bi·cu·cul·line

(bī'kū-kyū'lēn),
An alkaloid naturally occurring in the d-form; found in Dicentra cucullaria and Adlumia fungosa (family Fumariaceae) and several Corydalis species; a powerful convulsant that acts by antagonizing γ-aminobutyric acid, an inhibitory neurotransmitter.

bicuculline

A photosensitive alkaloid first derived from Dicentra cucullaria, which is also found in Adlumia fungosa and herbs of genus Corydalis and Fumariaceae. It is a competitive antagonist of the neurotransmitter gamma-aminobutyric acid at the GABAA receptor, and has been used in model systems for epilepsy.
References in periodicals archive ?
All recording slices were treated with phaclofen or bicuculine with asiatic acid various concentrations, while the other drug-untreated control was treated with phaclofen or bicuculine containing no asiatic acid.
The blocking effects are considerably greater in slices with concentration of 100 [micro]M with GABAA antagonist, bicuculine.
Dihydropyridine calcium channels blockers in experimental seizures by ischemia, bicuculine, electrical cortical shocks, nitrous oxide and alcohol withdrawal syndrome is caused due, have anticonvulsant effects [7].