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bicalutamide |
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bicalutamide /bi·ca·lu·ta·mide/ (bi″kah-loo´tah-mīd) an antiandrogen used in the treatment of prostatic carcinoma.
bicalutamide, an anticancer chemotherapy agent. indications It is prescribed in the treatment of metastatic prostate cancer. The drug acts by binding to androgen receptors within target cells, preventing androgens from binding to them. contraindications The drug should not be given to patients who have an allergic reaction to it. Bicalutamide should be used with caution in patients with moderate to severe liver dysfunction. adverse effects The side effects most often reported include hot flashes, general body pain, asthenia, constipation, nausea, and diarrhea. bicalutamide [bi″kah-loo´tah-mīd] an androgen antagonist used as an adjunct, in combination with a luteinizing hormone–releasing hormone analogue, in treatment of prostatic carcinoma; administered orally.
bicalutamide Warning - Hazardous drug! Casodex Pharmacologic class: Nonsteroidal antiandrogen Therapeutic class: Antineoplastic Pregnancy risk category X ActionAntagonizes effects of androgen at cellular level by binding to androgen receptors on target tissues AvailabilityTablets: 50 mg ⊘Indications and dosages ➣ Metastatic prostate cancer Adults: 50 mg P.O. once daily Contraindications• Hypersensitivity to drug PrecautionsUse cautiously in: Administration• Know that drug is given in combination with luteinizing hormone-releasing hormone (LHRH).
Adverse reactionsCNS: headache, weakness, dizziness, depression, hypertonia, paresthesia, lethargy CV: chest pain, peripheral edema, vasodilation, hypertension, thromboembolic disease EENT: pharyngitis GI: nausea, vomiting, diarrhea, constipation, abdominal pain, anorexia, dry mouth GU: urinary tract infection Musculoskeletal: bone and back pain Respiratory: dyspnea, cough Skin: rash, alopecia Other: food distaste, weight gain, edema, pain, hot flashes, flulike symptoms InteractionsDrug-drug. Warfarin: increased bicalutamide effects Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, cholesterol: increased levels Hemoglobin, white blood cells: decreased values Patient monitoring• Monitor prostate-significant antigen levels, CBC, and liver and kidney function test results. Patient teaching• Instruct patient to take drug at same time each day, along with prescribed LHRH analog. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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Nowadays, bicalutamide is the drug of choice that is slowly replacing flutamide because of its fewer recorded side effects. Therefore, he was commenced on bicalutamide in July 2005, resulting in a fall in his PSA to 0. Contemporary therapies have varying mechanisms of action, including combined androgen blockage (gonadotrophin-releasing hormone agonist [eg, goserelin and leuprolide] combined with an androgen receptor antagonist [eg, flutamide, bicalutamide, and nilutamide]), gonadotrophin-releasing hormone antagonists (eg, abarelix), and 5[alpha]-reductase inhibitors (eg, finasteride and dutasteride). |
bicalutamide |
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