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Bextra

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Bextra®
Cardiology Bucindolol An investigational nonselective beta-blocker with vasodilating properties in phase III clinical trials for treating CHF, removed from the marketplace. See BEAT, BEST Pain management Valdecoxib A next-generation of a proprietary Cox-2-specific inhibitors.


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And physicians are becoming more leery of thinking that every new drug represents a 'breakthrough' or improvement over existing therapies--something that resulted in part from the problems around Vioxx and Bextra," she said.
And it recommends a "black box warning"--the most serious possible--on the detailed package insert of all three Cox-2 drugs: Vioxx, Celebrex and Bextra.
Based on this, Vioxx and Bextra may be associated with a higher risk of a heart attack because they are more potent inhibitors of COX-2 enzymes than Celebrex.
 
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