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beta-lactamase
(redirected from Betalactamase)

   Also found in: Wikipedia 0.06 sec.
be·ta-lac·ta·mase (bt-lkt-ms, -mz)
n.
Any of various enzymes that are produced by gram-negative bacteria and hydrolyze lactam rings, thereby inactivating penicillin and cephalosporin antibiotics. Also called cephalosporinase, penicillinase.

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Using amoxicillin-clavulanate in combination with ceftazidime, cefiriaxone, and aztreonam, we performed the double disk synergy test to determine whether this strain was an extended-spectrum betalactamase producer as described elsewhere (3); augmentation of the zone at the junction of amoxicillin-clavulanate and aztreonam/cefiriaxone/cefiazidime zones confirmed that indeed it was.
 
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