beta-lactamase

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Related to Beta-lactamases: Carbapenem

β-lac·ta·mase

(lak'tă-mās),
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity. The ability of an organism to produce a β-lactamase may be chromosomal and constitutive or a plasmid-associated acquired property.

β-lactamase

/β-lac·ta·mase/ (lak´tah-mās) any of a group of enzymes, produced by almost all gram-negative bacteria, that hydrolyze the β-lactam ring of penicillins and cephalosporins, destroying their antibiotic activity. Individual enzymes may be called penicillinases or cephalosporinases based on their specificities.

beta-lactamase

(bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

beta-lactamase

[-lak′təmāz]
Etymology: lactam, a cyclic amide, ase, enzyme
a bacterial enzyme that catalyzes the hydrolysis of the beta-lactam ring of some penicillins and cephalosporins, producing penicilloic acid and rendering the antibiotic ineffective. Also called cephalosporinase, penicillinase.

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.

β-lactamase

either of two enzymes: β-lactamase I is penicillinase; β-lactamase II is cephalosporinase.
References in periodicals archive ?
AVYCAZ demonstrated in vitro activity against Enterobacteriaceae in the presence of some beta-lactamases and extended-spectrum beta-lactamases (ESBLs) of the following groups: TEM, SHV, CTX-M, Klebsiella pneumoniae carbapenemase (KPCs), AmpC, and certain oxacillinases (OXA).
Resistance to carbapenem is often mediated by production of MBL, a class B-type beta-lactamases that requires bivalent metal ion, usually Zn for their activity.
Extended-spectrum beta-lactamase (ESBL) production in bacterial isolates is becoming a worldwide problem.
Multidrug resistance in Gram-negative bacteria that produce extended-spectrum beta-lactamases (ESBLs).
He and his colleagues chemically modified penicillin so that it releases a molecular fragment when a beta-lactamase cuts the ring.
CXA-201 and CAZ-AVI provide broad-spectrum, gram-negative coverage and stability against ESBLs and CAZ-AVI has the added advantage of expanded coverage of some class C beta-lactamases and the class A carbapenemases KPC," said Decision Resources Analyst Maria Ascano, Ph.
Prevalence of Escherichia coli carrying extended-spectrum beta-lactamases (CTX-M and TEM-52) from broiler chickens and turkeys in Great Britain between 2006 and 2009.
NXL104 is a significant advance, as it is able to inhibit a broader range of beta-lactamases than currently marketed inhibitors.
NXL 104 inhibits bacterial enzymes called beta-lactamases that break down beta-lactam antibiotics including cephalosporins.
TM] is a combination of a carbapenem antibiotic (RPX2003) combined with a second drug (RPX7009) that acts as an inhibitor of bacterial beta-lactamases.

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