beta cell

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Related to Beta-cell: Islet of Langerhans

beta cell

n.
1. Any of the insulin-producing cells of the islets of Langerhans in the pancreas.
2. Any of the basophilic chromophil cells located in the anterior lobe of the pituitary gland.

beta cell

A pancreatic endocrine cell that comprises up to 80% of the cells in the islets of Langerhans, which produces and releases insulin. Beta cells are destroyed or dysfunctional in type-1 diabetes, function suboptimally in type-2 diabetes and become neoplastic in insulinomas. Beta cells were once distinguished solely on the basis of differential staining from other cells designated A, C and D

beta cell

1. Any of the insulin-secreting cells of the pancreas that constitute the bulk of the islets of Langerhans. Synonym: B cell
2. A basophil cell of the adenohypophysis (anterior pituitary gland).
See also: cell
References in periodicals archive ?
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.
The researchers tried adding S961 directly to mouse beta-cells in the lab, but there was no observed effect.
Emerging therapies are aimed not just at glycaemic control but also preservation of beta-cell function and reversal of insulin resistance.
In the controlled portion of the study, metformin-treated patients with type 2 diabetes were randomized to receive BYETTA (n=36) or Lantus (n=33) and measures of beta-cell function, blood sugar control and weight change were compared.
In addition to preserving beta-cell function as observed in human islets, mTOT modulators have been shown in animal models of type 2 diabetes to improve insulin signaling, decrease calorie-storing "white fat," and increase levels of calorie burning "brown fat.
NGM has established a robust translational research platform based on human biology that is capable of discovering novel drug targets, and we look forward to applying our technology to the emerging area of beta-cell regeneration.
14 weeks of liraglutide therapy in subjects with T2DM significantly improves 1st phase insulin secretion and maximal beta-cell secretory capacity.
The researchers detected beta-cell autoimmunity in 18 of the children they tested.
KineMed's second product program in diabetes offers a pre-clinical measure of pancreatic beta-cell proliferation.
Rather, the beta-cell growth in insulin-resistant states occurs by "epithelial-to-mesenchymal transition," a mechanism in which cells take on a more primitive form and begin replicating.
In a poster presentation entitled, "The Deuterated-Glucose Disposal Test (2H-GDT): A Sensitive, High-Throughput Measure of Insulin Resistance and the Adequacy of Pancreatic Beta-Cell Compensation in vivo", the Company presented data from a new study comparing the KineMarker(TM) insulin resistance test with the traditional hyperinsulinemic-euglycemic glucose clamp method in lean individuals and obese subjects with Metabolic Syndrome.
An antibody test developed last year detects the disease after beta-cell destruction has begun but before overt symptoms appear (SN: 6/18/88, p.