Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell
The researchers tried adding S961 directly to mouse beta-cells
in the lab, but there was no observed effect.
Emerging therapies are aimed not just at glycaemic control but also preservation of beta-cell
function and reversal of insulin resistance.
In the controlled portion of the study, metformin-treated patients with type 2 diabetes were randomized to receive BYETTA (n=36) or Lantus (n=33) and measures of beta-cell
function, blood sugar control and weight change were compared.
In addition to preserving beta-cell
function as observed in human islets, mTOT modulators have been shown in animal models of type 2 diabetes to improve insulin signaling, decrease calorie-storing "white fat," and increase levels of calorie burning "brown fat.
NGM has established a robust translational research platform based on human biology that is capable of discovering novel drug targets, and we look forward to applying our technology to the emerging area of beta-cell
14 weeks of liraglutide therapy in subjects with T2DM significantly improves 1st phase insulin secretion and maximal beta-cell
The researchers detected beta-cell
autoimmunity in 18 of the children they tested.
KineMed's second product program in diabetes offers a pre-clinical measure of pancreatic beta-cell
Rather, the beta-cell
growth in insulin-resistant states occurs by "epithelial-to-mesenchymal transition," a mechanism in which cells take on a more primitive form and begin replicating.
In a poster presentation entitled, "The Deuterated-Glucose Disposal Test (2H-GDT): A Sensitive, High-Throughput Measure of Insulin Resistance and the Adequacy of Pancreatic Beta-Cell
Compensation in vivo", the Company presented data from a new study comparing the KineMarker(TM) insulin resistance test with the traditional hyperinsulinemic-euglycemic glucose clamp method in lean individuals and obese subjects with Metabolic Syndrome.
An antibody test developed last year detects the disease after beta-cell
destruction has begun but before overt symptoms appear (SN: 6/18/88, p.