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beta-amyloid |
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beta-amyloid A4, β—amyloid Neurology A 4 kD polypeptide encoded on chromosome 21 arising from altered processing of amyloid precursor protein, an integral membrane glycoprotein secreted as a truncated carboxyl-terminal molecule; BA
forms plaques in the brains of Pts with Alzheimer's disease–AD, Down syndrome, infectious encephalopathy, cerebral amyloid angiopathy; BA is found in skin, intestine, adrenal gland. See Alzheimer's disease, Amyloid, Presenilin. Cf
Alpha2-macroglobulin. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| The team further reports that in the Alzheimer's mice, the drug reduced beta-amyloid plaques in the hippocampus but not in the amygdala. 21, RC 120;2001:1-5), beta-amyloid peptide has long been thought to be responsible for the build-up of plaques in the brain that is endemic to Alzheimer's disease. Due to challenges in synthesis due to their structure, beta-amyloid peptides with sequences 1-44 to 1-48 have not been commercially available until now. |
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