ADRB3

(redirected from Beta-3 adrenoceptor)

ADRB3

A gene on chromosome 8p12 that encodes beta-1-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which mediates catecholamine-induced activation of adenylate cyclase. ADRB3 is located primarily in adipose tissue and is involved in regulating lipolysis and thermogenesis.
References in periodicals archive ?
Mirabegron is a potent and selective beta-3 adrenoceptor agonist.
The selective beta-3 adrenoceptor agonist mirabegron is effective and well tolerated in patients with overactive bladder syndrome.
Mirabegron would represent the first oral OAB drug treatment with a completely new mode of action since the launch of oxybutynin several decades ago, and, if approved, would represent the first beta-3 adrenoceptor agonist to ever come to the market.
Mirabegron is a potent and selective beta-3 adrenoceptor (Beta3-AR) agonist which activates Beta3-ARs on the detrusor muscle of the bladder to facilitate filling of the bladder and storage of urine(3,4).
Phase III contains three first-in-class molecules including beta-3 adrenoceptor agonists and cell therapy.
These include platelet acetylcholine blockers, Beta-3 adrenoceptor agonists, calcium influx inhibitors and intracellular calcium modulators and combinational therapies employing molecules which are Beta-3 adrenoceptor agonists, muscarinic receptor antagonists.