ADRB2

(redirected from Beta-2 adrenoreceptor)

ADRB2

A gene on chromosome 5q31-q32 that encodes beta-2-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which mediates catecholamine-induced activation of adenylate cyclase. ADRB2 binds epinephrine with a 30-fold greater affinity than it does with norepinephrine.
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That observation, adds Bond, was an indication that blocking the receptor, scientifically known as beta-2 adrenoreceptor, might be a safer and more effective strategy for long-term asthma management than stimulating it.
During the current study, the researchers failed to trigger the development of asthma-like symptoms in a mouse model in which the beta-2 adrenoreceptor gene had been removed, compared to the mouse model with the intact receptor gene.
Propanolol, the first beta-blocker to be widely used, is nonselective for beta-1 and beta-2 adrenoreceptors.