beta-secretase

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beta-secretase

(bā-tă-sē-krĕ-tāz),
Agent that exists in two isoforms; protein with homology to the pepsin family of aspartyl proteases involved in the cleavage of beta-amyloid precursor protein; the gene for this protein is located on chromosome 11.

BACE1

B-site amyloid precursor protein (APP) cleaving enzyme. An aspartic-acid protease encoded by BACE1 on chromosome 11q23.2.-q23.3, which is linked to the pathogenesis of Alzheimer's disease and the formation of myelin sheaths in peripheral nerve cells. BACE1 is a transmembrane aspartic protease (beta-secretase) found in the Golgi apparatus, trans-Golgi network, secretory vesicles, and endosomes. It cleaves amyloid precursor protein (APP) in the brain into amyloid beta peptide, a major component of the amyloid plaques of Alzheimer's disease (AD), the deposition of which is the central pathology in AD, for which BACE1 is potential therapeutic target.
References in periodicals archive ?
On February 27, 2015, the Company announced that its partner Boehringer Ingelheim has voluntarily placed a temporary clinical hold on BI 1181181-an orally-active beta secretase (BACE) inhibitor being evaluated in Phase 1 clinical trials for the treatment and prevention of Alzheimer's disease-and has notified regulatory agencies of its decision.
16, 2014 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) and AstraZeneca today announced an agreement to co-develop and commercialize AZD3293, an oral beta secretase cleaving enzyme (BACE) inhibitor currently in development as a potential treatment for Alzheimer's disease.
Pratico said that their research has shown that 12/15-Lipoxygenase controls Beta secretase (BACE-1), an enzyme that is key to the development of amyloid plaques in Alzheimer's patients.
There is compelling evidence that sAPPbeta, the ectodomain of amyloid precursor protein (APP) shed through beta secretase cleavage, is an important component in the pathogenesis of AD," said Joe Bertelsen, neuroscience product manager, Covance.
The problem with most proposed methods of blocking beta secretase, the study found, is that they are designed to work outside of the affected brain cells.
Over the course of his career, Audia's scientific work has contributed to more than 12 development candidates, including transformative contributions to the treatment of Alzheimer's disease through his discovery of both the first gamma secretase inhibitor and an industry-leading beta secretase inhibitor.
Researchers reported results of an early-stage, randomized, double-blind, placebo-controlled, multiple-dose study of the experimental medication MK-8931 (Merck), which inhibits beta secretase - one of two enzymes that produce beta-amyloid - in people with mild-to-moderate Alzheimer's.
Amyloid peptides are produced when a long brain protein known as the amyloid precursor protein (APP) is cut in two by the enzyme beta secretase, and then cut once again by a second enzyme known as gamma secretase.
Amyloid beta peptides derive from amyloid precursor protein (APP) by proteolytic cleavage by beta secretase and gamma secretase.
1, 2014 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) and AstraZeneca today announced enrollment of the first patient into AMARANTH, a Phase II/III study of an oral beta secretase cleaving enzyme (BACE) inhibitor currently in development as a potential treatment for Alzheimer's disease.
Key classes of mechanism of action include immunotherapy, NMDA agonists, acetylcholine inhibitors, gamma secretase modulators, serotonin receptor antagonists, muscarinic receptor agonists, alpha secretase enhancers, beta secretase inhibitors, tau inhibitors and non-steroidal anti-inflammatory classes of drugs.
Morgan described proof-of-concept screening of the DirectSelect(TM) libraries against three kinase and one protease target, including the cancer targets Aurora A kinase and Gleevec-resistant mutant Abl T315I kinase, the inflammation target p38 map kinase, and the Alzheimer's target beta secretase.