beta-lactamase

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β-lac·ta·mase

(lak'tă-mās),
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity. The ability of an organism to produce a β-lactamase may be chromosomal and constitutive or a plasmid-associated acquired property.

β-lactamase

/β-lac·ta·mase/ (lak´tah-mās) any of a group of enzymes, produced by almost all gram-negative bacteria, that hydrolyze the β-lactam ring of penicillins and cephalosporins, destroying their antibiotic activity. Individual enzymes may be called penicillinases or cephalosporinases based on their specificities.

beta-lactamase

(bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

beta-lactamase

[-lak′təmāz]
Etymology: lactam, a cyclic amide, ase, enzyme
a bacterial enzyme that catalyzes the hydrolysis of the beta-lactam ring of some penicillins and cephalosporins, producing penicilloic acid and rendering the antibiotic ineffective. Also called cephalosporinase, penicillinase.

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.

β-lactamase

either of two enzymes: β-lactamase I is penicillinase; β-lactamase II is cephalosporinase.
References in periodicals archive ?
Detection of AmpC beta lactamases production in Escherichia coli & Klebsiella by an inhibitor based method.
Evolution and spread of SHV extended-spectrum beta lactamases in gram-negative bacteria.
The production of beta lactamase by bacteria is one of the more common mechanisms that can cause certain widely used antibiotics to be ineffective in treating infections," stated Dr.
By increasing the already significant spectrum of activity of ceftaroline, including MRSA, with the addition of the beta lactamase inhibitor NXL 104, we will have achieved the premier, broad- spectrum antibiotic presently available.
We therefore undertook this study to estimate the presence of Amp C beta lactamases in certain Gram-negative bacteria by inhibitor based method using boronic acid (BA) (7) and also asses if this test could be used to differentiate between ESBLs and amp C producers.
Metallo beta lactamase producing Pseudomonas aeruginosa in a hospital from rural area.
Plasmid mediated AmpC beta lactamases production was further confirmed by the AmpC disk test as described by Black et al (7).
Plasmid mediated extended spectrum beta lactamase (CTX-M-3 like) from India and gene association with insertion sequence ISEcp1.
The compound combines amoxicillin, an extended-spectrum antibiotic, with clavulanate, which inactivates beta lactamases and thus protects amoxicillin from destruction.
Extended spectrum beta lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.
For detection of various types of extended spectrum beta lactamases (ESBLs), molecular methods are the best but the facilities are not available in most of the laboratories especially in the developing countries.