Beta Propeller

A molecular domain based on 4- to 8-stranded antiparallel and twisted beta-sheets, arranged toroidally around a central tunnel. Beta propellers have a wide range of different functions, and proteins containing these domains have been implicated in the pathogenesis of a variety of diseases such as cancer, Alzheimer’s disease, Huntington’s disease, arthritis, familial hypercholesterolemia, retinitis pigmentosa, osteogenesis, hypertension, and microbial and viral infections.