ubenimex

(redirected from Bestatin)

ubenimex

Alternative oncology
A competitive protease-inhibiting peptide isolated from the supernatant broth of cultured Streptomyces olivoreticuli that inhibits aminopeptidases B and N and leukotriene A4 hydrolase. Ubenimex stimulates the immune system, activates macrophages, increases production and secretion of IL-1 and IL-2, and stimulates T cells and haematopoiesis. It is in clinical trials for acute myeloid leukaemia and may be effective in treating various cancers, including Hodgkin lymphoma, leukaemia, melanoma, and cancers of the bladder, oesophagus, head and neck, lung and stomach.
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The effects of bestatin on humoral response to sheep erythrocytes in non- treated and cyclophosphamide- immunocompromised mice.
5% deoxycholate, 1 mM PMSF and protease inhibitor cocktail (2 mM [4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride], 14 [micro]M (N-(trans-epoxysuccinyl)-L-leucine 4-guanidinobutylamide], 130 [micro]M bestatin, 0.
Effect of protease inhibitors on endogenous or exogenous [beta]-galactosidase in human fibroblasts Inhibitor Protease [beta]- [beta]- Galactosidase Galactosidase (endogenous) * (exogenous) ** None 100 100 E-64 Thiol 430 229 (Cysteine) *** Leupeptin Thiol 460 222 (Cysteine) *** Antipain Thiol 490 224 (Cysteine) *** Chymostatin Thiol 520 188 (Cysteine) *** Elastatinal Elastase 60 103 Pepstatin Pepsin 100 97 Phosphoramidon Metallopeptidase 110 88 Bestatin Aminopeptidase 110 90 * Relative enzyme activity in human fibroblasts with cathepsin A deficiency (galactosialidosis).
Synthesis and structure-activity relationships of bestatin analogues, inhibitors of aminopeptidase.
1% sodium dodecyl sulfate) containing 100 mM sodium orthovanadate and a protease inhibitor cocktail containing 4-(2-aminoethyl benzenesulfonyl fluoride), pepstatin A, E-64, bestatin, leupeptin, and aprotinin (Sigma).
Dicho buffer estuvo compuesto de: 50 mM Tris-HCI (pH 8,0), 1 mM EDTA, 500 mM KCl, 2 mM ditiotreitol (DTT), y 0,05% coctel inhibidor de la proteasas (4-2-aminoetilbenzenesulfonil fluoride, pepstatin A, trans-epoxysuccinil-L-leucilamido 4-guanidino butano, bestatin, leupeptin y aprotinin; Sigma, St.
Randomized double-blind placebo-controlled trial of bestatin in patients with resected stage I squamous-cell lung carcinoma.
Genco found that, in test tube experiments, bestatin does not affect chemotaxis in neutrophils from healthy subjects, but it almost doubles the chemotactic activity in neutrophils from LJP patients.
3 g/1 g of tissue of 4-(2- aminoethyl) benzenesulfonyl fluoride, bestatin, pepstatin A, E-64, leupeptin, 1,10-phenanthroline (Sigma, St.
The protease inhibitors initially surveyed were antipain, aprotinin, bestatin, chymostatin, leupeptin, aminoethylbenzenesulfonyl fluoride (AEBSF), and phosphoramidon.
Bestatin was from Cambridge Research Biochemicals (Wilmington, DE).