Among the effective herbal derivatives, Berberis aristata
has aroused great interest for its glucose-lowering and lipid-lowering activity.
Berberine is a natural plant extract from Berberis aristata
bark, that reduces cholesterolemia by increasing LDL-Cholesterol receptor on the liver cell surface and inhibiting TG biosynthesis via the inhibition of Proprotein convertase subtilisin/kexin type 9 (PCSK9) and the activation of 5'AMP activated proteokinase (Brusq et al.
Berberine, an alkaloid extract derived from plants such as Berberis aquifolium, Berberis vulgaris, Berberis aristata
, Hydrastis canadensis and Coptis chinensis, provides further multidimensional support.
e Berberis aristata
was reported by HPLC-UV and observed the peak at retention time 11.
Although, berberine is phototoxic  but Berberis aristata
extract found safe with LD50greater than 5000 mg/kg body weight in mice  which is in accordance to this research in which it showed higher LC50.
DC (commonly known as Tree turmeric or Indian Barberry) has previously demonstrated beneficial effects in dyslipidaemia with significant reductions in total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol attributed to up-regulation of LDL-receptor expression.
Evaluation of Adhatoda vasica and Berberis aristata
as wound healing agents in rats.
, Rosa moschata, Skimmia laureola, Salix alba, Viola spp.
Hypoglycaemic activity of different fractions of Berberis aristata
root-bark in normal and alloxan diabetic rabbits.
22], reported that Berberis aristata
roots contain 3.
Of 132 medicinal plant species the following 22 are considered rare and endangered; Aconitum atrox, Dactylorhiza hatagirea, Fritillaria roylei, Thalictrum foliolosum, Berberis aristata
, Artemisia maritime, Delphinium cashmerianum, Gloriosa superb, Saussurea obvallata, Betula utilis, Nardostachys jatamansi, Swertia chiraita, Rheum austral, Rheum webbianum, Podophylum hexandrum, Hippophea salicifolia, Bergenia ligulata, Bergenia stracheyi, Arnebia benthamii, Rhododendron arboretum, Aegle marmelos, Lyonia ovalifolia and Waldhemia glabra.
Berberine, sourced from Berberis aristata
roots, shows significant anti-microbial activity when evaluated against the oral pathogens Streptococcus mutatis and Fusobacterium nucleatum, Mr.