benznidazole


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benznidazole

An antiprotozoal drug used mainly to treat South American trypanosomiasis (Chagas' disease). The drug is on the WHO official list.
References in periodicals archive ?
An additional study of the safety and pharmacokinetics (how the body absorbs, distributes and clears the drug) of benznidazole in pediatric patients two to 12 years of age provided information for dosing recommendations down to two years of age.
88) Treatment with nifurtimox or benznidazole may be indicated for acute and indeterminate chronic disease to decrease symptoms and clinical course, but must be obtained from the CDC and administered under an investigational protocol.
KaloBios has set out key near-term goals in executing this strategy: Benznidazole - expect to have U.
Background: The current treatment of Chagas disease, endemic in Latin America and emerging in several countries, is limited by the frequent side effects and variable efficacy of benznidazole.
Adverse events after the use of benznidazole in infants and children with Chagas' disease.
Ferraz ML, Gazinelli RT, Alves RO, Urbina JA, Romanha AJ Absence of CD4+ T lymphocytes, CD8+ T lymphocytes or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in the treatament of experimental acute Trypanosoma cruzi infection.
Available treatments include nifurtimox (available from CDC Drug Service, telephone 404-639-3670) or benznidazole (only distributed outside of the United States).
KaloBios announced July 1 that it emerged from Chapter 11 bankruptcy effective June 30 with $14 million in equity financing and also acquired the rights from Savant Neglected Diseases LLC to develop benznidazole for the treatment of Chagas disease.
M2 EQUITYBITES-December 4, 2015-KaloBios Pharmaceuticals to acquire benznidazole programme for Chagas Disease from Savant
M2 PHARMA-December 4, 2015-KaloBios Pharmaceuticals to acquire benznidazole programme for Chagas Disease from Savant
Introduced in the 1960s and 1970s nifurtimox (Nx) and benznidazole (Bz), two nitroheterocyclic drugs, are currently used for treatment of Chagas disease although their availability is limited and are not approved by the FDA.