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benserazide

   Also found in: Wikipedia 0.03 sec.
benserazide /ben·ser·a·zide/ (ben-ser´ah-zīd) an inhibitor of decarboxylation of levodopa in extracerebral tissues, used in combination with levodopa as an antiparkinsonian agent.
benserazide
[ben-ser′ah-zīd]
an inhibitor of the decarboxylation of peripheral levodopa to dopamine, having actions similar to those of carbidopa. When given with levodopa, benserazide produces higher brain concentrations of dopamine with lower doses of levodopa, thus lessening the side effects seen with higher doses. It is used orally in conjunction with levodopa as an antiparkinsonian agent.


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[33] Patients with early Parkinson's disease were randomly divided into two primary groups: group 1 (n=249) received traditional L-dopa therapy (L-dopa combined with benserazide, a peripheral dopa decarboxylase inhibitor that prevents the premature conversion of L-dopa to dopamine), and group 2 (n=271) received traditional L-dopa therapy combined with selegiline.
 
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