benserazide


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benserazide

 [ben-ser´ah-zīd]
an inhibitor of the decarboxylation of peripheral levodopa to dopamine, having actions similar to those of carbidopa. When given with levodopa, benserazide produces higher brain concentrations of dopamine with lower doses of levodopa, thus lessening the side effects seen with higher doses. It is used orally, in conjunction with levodopa, as an antiparkinsonian agent.

ben·ser·a·zide

(ben-ser'ă-zīd),
An l-aromatic amino acid decarboxylase (dopa decarboxylase) inhibitor resembling carbidopa in action; given in combination with levodopa as an antiparkinsonian regimen. The benserazide prevents peripheral destruction of levodopa and thus reduces cardiovascular side effects of treatment.

benserazide

/ben·ser·a·zide/ (ben-ser´ah-zīd) an inhibitor of decarboxylation of levodopa in extracerebral tissues, used in combination with levodopa as an antiparkinsonian agent.

benserazide

[ben-ser′ah-zīd]
an inhibitor of the decarboxylation of peripheral levodopa to dopamine, having actions similar to those of carbidopa. When given with levodopa, benserazide produces higher brain concentrations of dopamine with lower doses of levodopa, thus lessening the side effects seen with higher doses. It is used orally in conjunction with levodopa as an antiparkinsonian agent.

benserazide

A dopamine precursor drug given in conjunction with LEVODOPA in the treatment of PARKINSON'S DISEASE to prevent the breakdown of levodopa in the body. A brand name is Madopar.
References in periodicals archive ?
levodopa in combination with benserazide (ATC: N04BA11) only administration form REK;
In our country, carbidopa- benserazide combinations that prolong the active period of L-Dopa by preventing it from converting to dopamine in the periphery are available.
25 mg/kg of benserazide tablets (Roche Diagnostics, Penzberg, Germany) dissolved in sterile saline once daily at 15:00 for another 21 consecutive days.
Treatment of restless legs syndrome with levodopa plus benserazide.
Drug Mechanism of action L-DOPA DA precursor L-DOPA + benserazide or carbidopa DA precursor + peripheral dopa- decarboxylase inhibitor Bromocriptine, pergolide, DA receptor agonists pramipexole, ropinirole Selegiline, rasagiline Monoamine oxidase B inhibitors Increase of DA release and Amantadine glutamate NMDA receptor antagonist Trihexyphenidyl, benztropine Muscarinic receptor antagonists Catechol-O- Entacapone, tolcapone methyltransferase inhibitors Adapted from [108].
In a paper (containing 90 scientific references) published in Clinical Pharmacology, Hinz, Alvin Stein, and Ted Cole note that the only indication for carbidopa and benserazide is the management of L-dopa-induced nausea.
8mmol/L); (c) a 2-year history of Parkinson's disease treated with 125mg benserazide tid; and (d) a 2-month history of visual hallucinations that were being controlled with 1.
A habilidade orofaringea da degluticao na DP foi examinada em 19 pacientes antes e apos a administracao de 200mg de Levodopa em combinacao com benserazide (50mg).
2010, Simultaneous voltametric determination of levodopa, carbidopa and benserazide in pharmaceuticals using multivariate calibration.
It is often given with a peripheral decarboxylase inhibitor, eg, carbidopa or benserazide, to reduce the breakdown of L-dopa outside of the brain.
In rats, a combination of levodopa, benserazide, and disulfiram injected intraperitoneally increases striatal contents of DOPAL to about 2 ng/mg protein (about 13 pmol/mg), without a semichronic effect on striatal dopamine contents after repeated injections (10).