BCR

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BCR

Breakpoint cluster region. A 5.8-kb DNA segment on chromosome 22q11.23, which, in contrast to the well-studied BCR-ABL fusion protein related to malignant transformation of pluripotent haematopoietic stem cells in CML, encodes a gene product of unknown function, which has serine/threonine kinase activity and is a GTPase-activating protein for p21rac.

In CML there is a reciprocal translocation between chromosome 9q34—a site which contains the human homolog of the Abelson viral oncogene, c-abl—and chromosome 22q1, the location of the breakpoint cluster region; this translocation results in formation of the Philadelphia chromosome, which transcribes a hybrid mRNA, encoding a protein with tyrosine kinase activity.
References in periodicals archive ?
The improved plan will have numerous benefits including: Better travel times for O-Bahn bus passengers - on average, daily bus commute times reduced by seven minutes, Increased capacity and reduced congestion on Adelaide s Inner City Ring Route, Closing Rundle Road returning more than 3000 square metres of land to Rundle Park, Significant improvements to the East End precinct, Support about 450 jobs during construction, Provide for future EastLink tram corridor, Strong benefit cost ratio.
Studies have shown a high economic benefit cost ratio (BCR) from public investment through the injection of income and employment into the North Wales economy which the Celtic Sea cruise market has to offer.
For instance, the Benefit Cost Ratio to rail users in the east is 5.
The Australian Transport Council (ATC) have identified that the benefit cost ratio (BCR), the net present value (NPV), and first-year rate of return (FYRR) decision criteria are appropriate inputs to project prioritization, mutual exclusive project selection, and optimal timing, respectively.
Campaigners insist the HS2 business case has fallen apart in recent weeks after: * The government's crucial benefit cost ratio (BCR) was revised down for a fourth time.
Broadly speaking, ROI is reflected by numbers: these include the benefit cost ratio (B/C; a number greater than one implies that the program is justified on both internal efficiency and external effectiveness grounds); the net present value (NPV; a number greater than zero implies that building the program today is justified instead of waiting for the future); and the internal rate of return (IRR; when the rate of return obtained from program implementation exceeds the market interest rate; this is the measure used to determine returns from financial investing).
In order to calculate benefit cost ratio, the private costs of pesticides were added to the producer rent yielding the gross value added from this input factor.
In the particular case of PVM-60/3 an increment of speed-up was simultaneously detected with an increment in generalisation capability, hence the benefit cost ratio is not registered.
STDT (Storage Technology Development and Transfer Pakistan) has tried to mechanize the procurement of wheat from the farms but in the location where trials were carried out the estimated, benefit cost ratio was only 0.
Since benefits are greater than costs the project is shown to produce a favorable county benefit cost ratio of $4 54: 1.
Financial modelling shows the State s economy will benefit, with a benefit cost ratio of $2.
8:1 benefit cost ratio (HM Treasury requires a minimum of 2:1; South Wales rail electrification was 4.